Clinical and biological implications of mutational spectrum in acute myeloid leukemia of FAB subtypes M4 and M5

The mutational spectrum and molecular characteristics of acute myelomonocytic lineage leukemia, namely acute myeloid leukemia (AML) French–American–British (FAB) subtypes M4 and M5, are largely unknown. In order to explore the mutational spectrum and prognostic factors of FAB-M4 and -M5, next-genera...

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Veröffentlicht in:	Cancer gene therapy 2018-04, Vol.25 (3-4), p.77-83
Hauptverfasser:	Cheng, Zhiheng, Hu, Kai, Tian, Lei, Dai, Yifeng, Pang, Yifan, Cui, Wei, Zhao, Hongmian, Qin, Tong, Han, Yu, Hu, Ning, Chen, Li, Wang, Chao, Zhang, Yijie, Wu, Depei, Ke, Xiaoyan, Shi, Jinlong, Fu, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283 692/53 Acute myelocytic leukemia Acute myeloid leukemia Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Bone marrow Disease-Free Survival Explosions Female Gene Expression Gene mutation Gene Therapy Genes Genetic aspects Hematopoietic stem cell transplantation Hematopoietic stem cells High-throughput screening (Biochemical assaying) Humans Leukemia Leukemia, Myeloid, Acute - classification Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Male Medical prognosis Medical research Methyltransferases Middle Aged Multivariate analysis Mutation Myeloid leukemia Neoplasm Proteins - genetics Runx1 protein Stem cell transplantation Stem cells Surgery Survival Rate White blood cell count
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