Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics
Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms,...
Gespeichert in:
Veröffentlicht in: | Oncogene 2018-05, Vol.37 (22), p.3039-3044 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 3044 |
---|---|
container_issue | 22 |
container_start_page | 3039 |
container_title | Oncogene |
container_volume | 37 |
creator | Shen, Peiye Jing, Ying Zhang, Ruiyun Cai, Mei-Chun Ma, Pengfei Chen, Haige Zhuang, Guanglei |
description | Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and signatures of neuroendocrine bladder cancer strikingly resembled those in conventional urothelial carcinoma, along with typically mixed histologies, supporting a common cellular origin. We identified pervasive age-related and APOBEC-mediated mutagenesis patterns, and one patient displayed a somatic fingerprint attributable to aristolochic acid exposure, an established etiology of urothelial cell carcinoma. Deep RNA sequencing revealed dysregulated tumorigenic pathways and novel fusion transcripts, including a targetable in-frame
PVT1
-
ERBB2
variant associated with aberrant expression of
ERBB2
gene (encoding HER2 receptor). Furthermore, we provided preliminary evidence that combined
TP53
and
RB1
depletion favored lineage switching from oncogene-addicted urothelial cancer cells to neuroendocrine-like tumor cells, and resulted in decreased response to targeted agents. Together, these data present the first high-resolution genomic portrait of neuroendocrine bladder cancer, which holds important implications for the biological understanding and rational treatment of this deadly disease. |
doi_str_mv | 10.1038/s41388-018-0192-5 |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2047225536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A572595684</galeid><sourcerecordid>A572595684</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-94d0444af131325820c3d219fe257c2593dd2015126163d29d3903e15c2905ca3</originalsourceid><addsrcrecordid>eNp1kc1q3TAQhUVoaW7SPkA3RdC1U2kk2dYyXJq2EOgmWQtFGjsKtuRKdqBvX11u0lBoEGIW8535O4R85OyCM9F_KZKLvm8YP3wNjTohOy67tlFKyzdkx7RijQYBp-SslAfGWKcZvCOnoJVQEuSOPO7TvGS8x1jCI9IRY5qDo0tOQ5hCHGkaaMQtJ4w-uRwi0rvJeo-ZOhtdDUuISwpxLXROE7ptspmmHMYQqY2eLmnFuAY70fUes11wW4Mr78nbwU4FPzzFc3J79fVm_725_vntx_7yunFS6LXR0jMppR244AJUD8wJD1wPCKpzoLTwHhhXHFre1oz2QjOBXDnQTDkrzsnnY9260K8Ny2oe0pZjbWmAyQ5AKdG-UKOd0IQ4pDVbN4fizKXqahvV9rJSF_-h6vNYT5Yi1ovhvwJ-FLicSsk4mCWH2ebfhjNzMNAcDTTVQHMw0Kiq-fQ08HY3o_-reHasAnAESk3FEfPLRq9X_QORsaWT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047225536</pqid></control><display><type>article</type><title>Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><creator>Shen, Peiye ; Jing, Ying ; Zhang, Ruiyun ; Cai, Mei-Chun ; Ma, Pengfei ; Chen, Haige ; Zhuang, Guanglei</creator><creatorcontrib>Shen, Peiye ; Jing, Ying ; Zhang, Ruiyun ; Cai, Mei-Chun ; Ma, Pengfei ; Chen, Haige ; Zhuang, Guanglei</creatorcontrib><description>Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and signatures of neuroendocrine bladder cancer strikingly resembled those in conventional urothelial carcinoma, along with typically mixed histologies, supporting a common cellular origin. We identified pervasive age-related and APOBEC-mediated mutagenesis patterns, and one patient displayed a somatic fingerprint attributable to aristolochic acid exposure, an established etiology of urothelial cell carcinoma. Deep RNA sequencing revealed dysregulated tumorigenic pathways and novel fusion transcripts, including a targetable in-frame
PVT1
-
ERBB2
variant associated with aberrant expression of
ERBB2
gene (encoding HER2 receptor). Furthermore, we provided preliminary evidence that combined
TP53
and
RB1
depletion favored lineage switching from oncogene-addicted urothelial cancer cells to neuroendocrine-like tumor cells, and resulted in decreased response to targeted agents. Together, these data present the first high-resolution genomic portrait of neuroendocrine bladder cancer, which holds important implications for the biological understanding and rational treatment of this deadly disease.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/s41388-018-0192-5</identifier><identifier>PMID: 29535424</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/1 ; 38 ; 45 ; 45/23 ; 45/91 ; 631/67/1059/2326 ; 631/67/69 ; Age ; APOBEC Deaminases - genetics ; Apoptosis ; Aristolochic acid ; Bladder cancer ; Brief Communication ; Carcinoma, Neuroendocrine - genetics ; Care and treatment ; Cell Biology ; Diagnosis ; ErbB-2 protein ; Etiology ; Gene expression ; Gene Expression Profiling ; Gene Regulatory Networks ; Genetic aspects ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic screening ; Genomes ; Genotype ; Health aspects ; High-Throughput Nucleotide Sequencing - methods ; Human Genetics ; Humans ; Identification and classification ; Internal Medicine ; Malignancy ; Medicine ; Medicine & Public Health ; Methods ; Mutagenesis ; Mutation ; Neuroendocrine tumors ; Oncology ; p53 Protein ; Receptor, ErbB-2 - genetics ; Retinoblastoma Binding Proteins - genetics ; Ribonucleic acid ; RNA ; Tumor cells ; Tumor Suppressor Protein p53 - genetics ; Ubiquitin-Protein Ligases - genetics ; Urinary bladder ; Urinary bladder carcinoma ; Urinary Bladder Neoplasms - genetics ; Urothelial cancer ; Urothelial carcinoma ; Whole Exome Sequencing - methods ; Whole Genome Sequencing - methods</subject><ispartof>Oncogene, 2018-05, Vol.37 (22), p.3039-3044</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-94d0444af131325820c3d219fe257c2593dd2015126163d29d3903e15c2905ca3</citedby><cites>FETCH-LOGICAL-c439t-94d0444af131325820c3d219fe257c2593dd2015126163d29d3903e15c2905ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41388-018-0192-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41388-018-0192-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29535424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Peiye</creatorcontrib><creatorcontrib>Jing, Ying</creatorcontrib><creatorcontrib>Zhang, Ruiyun</creatorcontrib><creatorcontrib>Cai, Mei-Chun</creatorcontrib><creatorcontrib>Ma, Pengfei</creatorcontrib><creatorcontrib>Chen, Haige</creatorcontrib><creatorcontrib>Zhuang, Guanglei</creatorcontrib><title>Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and signatures of neuroendocrine bladder cancer strikingly resembled those in conventional urothelial carcinoma, along with typically mixed histologies, supporting a common cellular origin. We identified pervasive age-related and APOBEC-mediated mutagenesis patterns, and one patient displayed a somatic fingerprint attributable to aristolochic acid exposure, an established etiology of urothelial cell carcinoma. Deep RNA sequencing revealed dysregulated tumorigenic pathways and novel fusion transcripts, including a targetable in-frame
PVT1
-
ERBB2
variant associated with aberrant expression of
ERBB2
gene (encoding HER2 receptor). Furthermore, we provided preliminary evidence that combined
TP53
and
RB1
depletion favored lineage switching from oncogene-addicted urothelial cancer cells to neuroendocrine-like tumor cells, and resulted in decreased response to targeted agents. Together, these data present the first high-resolution genomic portrait of neuroendocrine bladder cancer, which holds important implications for the biological understanding and rational treatment of this deadly disease.</description><subject>14/1</subject><subject>38</subject><subject>45</subject><subject>45/23</subject><subject>45/91</subject><subject>631/67/1059/2326</subject><subject>631/67/69</subject><subject>Age</subject><subject>APOBEC Deaminases - genetics</subject><subject>Apoptosis</subject><subject>Aristolochic acid</subject><subject>Bladder cancer</subject><subject>Brief Communication</subject><subject>Carcinoma, Neuroendocrine - genetics</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Diagnosis</subject><subject>ErbB-2 protein</subject><subject>Etiology</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Regulatory Networks</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic screening</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Health aspects</subject><subject>High-Throughput Nucleotide Sequencing - methods</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Internal Medicine</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Mutagenesis</subject><subject>Mutation</subject><subject>Neuroendocrine tumors</subject><subject>Oncology</subject><subject>p53 Protein</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Retinoblastoma Binding Proteins - genetics</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Tumor cells</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><subject>Urinary bladder</subject><subject>Urinary bladder carcinoma</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urothelial cancer</subject><subject>Urothelial carcinoma</subject><subject>Whole Exome Sequencing - methods</subject><subject>Whole Genome Sequencing - methods</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc1q3TAQhUVoaW7SPkA3RdC1U2kk2dYyXJq2EOgmWQtFGjsKtuRKdqBvX11u0lBoEGIW8535O4R85OyCM9F_KZKLvm8YP3wNjTohOy67tlFKyzdkx7RijQYBp-SslAfGWKcZvCOnoJVQEuSOPO7TvGS8x1jCI9IRY5qDo0tOQ5hCHGkaaMQtJ4w-uRwi0rvJeo-ZOhtdDUuISwpxLXROE7ptspmmHMYQqY2eLmnFuAY70fUes11wW4Mr78nbwU4FPzzFc3J79fVm_725_vntx_7yunFS6LXR0jMppR244AJUD8wJD1wPCKpzoLTwHhhXHFre1oz2QjOBXDnQTDkrzsnnY9260K8Ny2oe0pZjbWmAyQ5AKdG-UKOd0IQ4pDVbN4fizKXqahvV9rJSF_-h6vNYT5Yi1ovhvwJ-FLicSsk4mCWH2ebfhjNzMNAcDTTVQHMw0Kiq-fQ08HY3o_-reHasAnAESk3FEfPLRq9X_QORsaWT</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Shen, Peiye</creator><creator>Jing, Ying</creator><creator>Zhang, Ruiyun</creator><creator>Cai, Mei-Chun</creator><creator>Ma, Pengfei</creator><creator>Chen, Haige</creator><creator>Zhuang, Guanglei</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20180501</creationdate><title>Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics</title><author>Shen, Peiye ; Jing, Ying ; Zhang, Ruiyun ; Cai, Mei-Chun ; Ma, Pengfei ; Chen, Haige ; Zhuang, Guanglei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-94d0444af131325820c3d219fe257c2593dd2015126163d29d3903e15c2905ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>14/1</topic><topic>38</topic><topic>45</topic><topic>45/23</topic><topic>45/91</topic><topic>631/67/1059/2326</topic><topic>631/67/69</topic><topic>Age</topic><topic>APOBEC Deaminases - genetics</topic><topic>Apoptosis</topic><topic>Aristolochic acid</topic><topic>Bladder cancer</topic><topic>Brief Communication</topic><topic>Carcinoma, Neuroendocrine - genetics</topic><topic>Care and treatment</topic><topic>Cell Biology</topic><topic>Diagnosis</topic><topic>ErbB-2 protein</topic><topic>Etiology</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Regulatory Networks</topic><topic>Genetic aspects</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic screening</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Health aspects</topic><topic>High-Throughput Nucleotide Sequencing - methods</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Internal Medicine</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Mutagenesis</topic><topic>Mutation</topic><topic>Neuroendocrine tumors</topic><topic>Oncology</topic><topic>p53 Protein</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Retinoblastoma Binding Proteins - genetics</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Tumor cells</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><topic>Urinary bladder</topic><topic>Urinary bladder carcinoma</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urothelial cancer</topic><topic>Urothelial carcinoma</topic><topic>Whole Exome Sequencing - methods</topic><topic>Whole Genome Sequencing - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Peiye</creatorcontrib><creatorcontrib>Jing, Ying</creatorcontrib><creatorcontrib>Zhang, Ruiyun</creatorcontrib><creatorcontrib>Cai, Mei-Chun</creatorcontrib><creatorcontrib>Ma, Pengfei</creatorcontrib><creatorcontrib>Chen, Haige</creatorcontrib><creatorcontrib>Zhuang, Guanglei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Peiye</au><au>Jing, Ying</au><au>Zhang, Ruiyun</au><au>Cai, Mei-Chun</au><au>Ma, Pengfei</au><au>Chen, Haige</au><au>Zhuang, Guanglei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>37</volume><issue>22</issue><spage>3039</spage><epage>3044</epage><pages>3039-3044</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and signatures of neuroendocrine bladder cancer strikingly resembled those in conventional urothelial carcinoma, along with typically mixed histologies, supporting a common cellular origin. We identified pervasive age-related and APOBEC-mediated mutagenesis patterns, and one patient displayed a somatic fingerprint attributable to aristolochic acid exposure, an established etiology of urothelial cell carcinoma. Deep RNA sequencing revealed dysregulated tumorigenic pathways and novel fusion transcripts, including a targetable in-frame
PVT1
-
ERBB2
variant associated with aberrant expression of
ERBB2
gene (encoding HER2 receptor). Furthermore, we provided preliminary evidence that combined
TP53
and
RB1
depletion favored lineage switching from oncogene-addicted urothelial cancer cells to neuroendocrine-like tumor cells, and resulted in decreased response to targeted agents. Together, these data present the first high-resolution genomic portrait of neuroendocrine bladder cancer, which holds important implications for the biological understanding and rational treatment of this deadly disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29535424</pmid><doi>10.1038/s41388-018-0192-5</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0950-9232 |
ispartof | Oncogene, 2018-05, Vol.37 (22), p.3039-3044 |
issn | 0950-9232 1476-5594 |
language | eng |
recordid | cdi_proquest_journals_2047225536 |
source | MEDLINE; SpringerLink Journals; Nature Journals Online |
subjects | 14/1 38 45 45/23 45/91 631/67/1059/2326 631/67/69 Age APOBEC Deaminases - genetics Apoptosis Aristolochic acid Bladder cancer Brief Communication Carcinoma, Neuroendocrine - genetics Care and treatment Cell Biology Diagnosis ErbB-2 protein Etiology Gene expression Gene Expression Profiling Gene Regulatory Networks Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetic screening Genomes Genotype Health aspects High-Throughput Nucleotide Sequencing - methods Human Genetics Humans Identification and classification Internal Medicine Malignancy Medicine Medicine & Public Health Methods Mutagenesis Mutation Neuroendocrine tumors Oncology p53 Protein Receptor, ErbB-2 - genetics Retinoblastoma Binding Proteins - genetics Ribonucleic acid RNA Tumor cells Tumor Suppressor Protein p53 - genetics Ubiquitin-Protein Ligases - genetics Urinary bladder Urinary bladder carcinoma Urinary Bladder Neoplasms - genetics Urothelial cancer Urothelial carcinoma Whole Exome Sequencing - methods Whole Genome Sequencing - methods |
title | Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T10%3A14%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comprehensive%20genomic%20profiling%20of%20neuroendocrine%20bladder%20cancer%20pinpoints%20molecular%20origin%20and%20potential%20therapeutics&rft.jtitle=Oncogene&rft.au=Shen,%20Peiye&rft.date=2018-05-01&rft.volume=37&rft.issue=22&rft.spage=3039&rft.epage=3044&rft.pages=3039-3044&rft.issn=0950-9232&rft.eissn=1476-5594&rft_id=info:doi/10.1038/s41388-018-0192-5&rft_dat=%3Cgale_proqu%3EA572595684%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2047225536&rft_id=info:pmid/29535424&rft_galeid=A572595684&rfr_iscdi=true |