contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age
The presence of maternal immunity in broilers does not preclude the successful protective immunization with an attenuated live reovirus vaccine at 1-day-old. This was recently demonstrated in a reovirus challenge model based on reovirus isolation from different organs (van Loon et al., 2002). Discri...
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| Veröffentlicht in: | Avian pathology 2003-02, Vol.32 (1), p.15-23 |
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| container_title | Avian pathology |
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| creator | Loon, Adriaan A.W.M. van Kosman, Willeke Zuilekorn, Hanneke I. van Riet, Suzanne van Frenken, Marijke Schijns, Virgil E.J.C |
| description | The presence of maternal immunity in broilers does not preclude the successful protective immunization with an attenuated live reovirus vaccine at 1-day-old. This was recently demonstrated in a reovirus challenge model based on reovirus isolation from different organs (van Loon et al., 2002). Discrimination between challenge and vaccine virus was made by specific monoclonal antibody. Notably, at the day of challenge the levels of circulating reovirus-specific antibodies proved to be minimal or undetectable. This suggested an antibody-independent vaccination-induced immunity under the chosen conditions. In the present study we assessed the contribution of specific humoral responses in the same experimental model, by evaluating the control of a virulent challenge infection in the complete absence of B cells as a result of cyclophosphamide treatment. These experiments were performed in both SPF white leghorn chickens and commercially available broilers with passively acquired maternal antibodies. Our data demonstrate that the virus is controlled in the absence of actively produced antibodies, and is independent of B lymphocytes. This suggests that cellular immunity is sufficient for protection of broilers with maternal antibodies against reovirus infection following early age vaccination with live reoviral vaccine. |
| doi_str_mv | 10.1080/0307945021000070679 |
| format | Article |
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This was recently demonstrated in a reovirus challenge model based on reovirus isolation from different organs (van Loon et al., 2002). Discrimination between challenge and vaccine virus was made by specific monoclonal antibody. Notably, at the day of challenge the levels of circulating reovirus-specific antibodies proved to be minimal or undetectable. This suggested an antibody-independent vaccination-induced immunity under the chosen conditions. In the present study we assessed the contribution of specific humoral responses in the same experimental model, by evaluating the control of a virulent challenge infection in the complete absence of B cells as a result of cyclophosphamide treatment. These experiments were performed in both SPF white leghorn chickens and commercially available broilers with passively acquired maternal antibodies. Our data demonstrate that the virus is controlled in the absence of actively produced antibodies, and is independent of B lymphocytes. This suggests that cellular immunity is sufficient for protection of broilers with maternal antibodies against reovirus infection following early age vaccination with live reoviral vaccine.</description><identifier>ISSN: 0307-9457</identifier><identifier>EISSN: 1465-3338</identifier><identifier>DOI: 10.1080/0307945021000070679</identifier><identifier>PMID: 12745377</identifier><language>eng</language><publisher>England: World Veterinary Poultry Association</publisher><subject>Animal vaccines ; Animals ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; B-lymphocytes ; B-Lymphocytes - cytology ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; Bursa of Fabricius - immunology ; cell-mediated immunity ; chickens ; Chickens - immunology ; Chickens - virology ; cyclophosphamide ; Cyclophosphamide - pharmacology ; humoral immunity ; Immunity (Disease) ; Infections ; maternal immunity ; monoclonal antibodies ; Orthoreovirus, Avian - immunology ; Poultry ; Poultry Diseases - immunology ; Poultry Diseases - prevention & control ; Reoviridae ; Reoviridae Infections - immunology ; Reoviridae Infections - prevention & control ; Reoviridae Infections - veterinary ; vaccination ; vaccines ; Viral Vaccines - immunology ; virulence ; viruses ; White Leghorn</subject><ispartof>Avian pathology, 2003-02, Vol.32 (1), p.15-23</ispartof><rights>Copyright Taylor & Francis Group, LLC 2003</rights><rights>Copyright Carfax Publishing Company Feb 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-f2f7f5cd0aae75b54cf71a90ad608020647b3da779f9d94dcf1db5c5a2a89f063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12745377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loon, Adriaan A.W.M. van</creatorcontrib><creatorcontrib>Kosman, Willeke</creatorcontrib><creatorcontrib>Zuilekorn, Hanneke I. van</creatorcontrib><creatorcontrib>Riet, Suzanne van</creatorcontrib><creatorcontrib>Frenken, Marijke</creatorcontrib><creatorcontrib>Schijns, Virgil E.J.C</creatorcontrib><title>contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age</title><title>Avian pathology</title><addtitle>Avian Pathol</addtitle><description>The presence of maternal immunity in broilers does not preclude the successful protective immunization with an attenuated live reovirus vaccine at 1-day-old. This was recently demonstrated in a reovirus challenge model based on reovirus isolation from different organs (van Loon et al., 2002). Discrimination between challenge and vaccine virus was made by specific monoclonal antibody. Notably, at the day of challenge the levels of circulating reovirus-specific antibodies proved to be minimal or undetectable. This suggested an antibody-independent vaccination-induced immunity under the chosen conditions. In the present study we assessed the contribution of specific humoral responses in the same experimental model, by evaluating the control of a virulent challenge infection in the complete absence of B cells as a result of cyclophosphamide treatment. These experiments were performed in both SPF white leghorn chickens and commercially available broilers with passively acquired maternal antibodies. Our data demonstrate that the virus is controlled in the absence of actively produced antibodies, and is independent of B lymphocytes. This suggests that cellular immunity is sufficient for protection of broilers with maternal antibodies against reovirus infection following early age vaccination with live reoviral vaccine.</description><subject>Animal vaccines</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>B-lymphocytes</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>Bursa of Fabricius - immunology</subject><subject>cell-mediated immunity</subject><subject>chickens</subject><subject>Chickens - immunology</subject><subject>Chickens - virology</subject><subject>cyclophosphamide</subject><subject>Cyclophosphamide - pharmacology</subject><subject>humoral immunity</subject><subject>Immunity (Disease)</subject><subject>Infections</subject><subject>maternal immunity</subject><subject>monoclonal antibodies</subject><subject>Orthoreovirus, Avian - immunology</subject><subject>Poultry</subject><subject>Poultry Diseases - immunology</subject><subject>Poultry Diseases - prevention & control</subject><subject>Reoviridae</subject><subject>Reoviridae Infections - immunology</subject><subject>Reoviridae Infections - prevention & control</subject><subject>Reoviridae Infections - veterinary</subject><subject>vaccination</subject><subject>vaccines</subject><subject>Viral Vaccines - immunology</subject><subject>virulence</subject><subject>viruses</subject><subject>White Leghorn</subject><issn>0307-9457</issn><issn>1465-3338</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9lr9BYIGF2IXo8kkmcxsClL8goIL7TqcySS9qTNJTTK33r_jL23uvQOClDabLM7zvBzOi9BLSt5T0pIPhBHZcUFqSsqTpJHdI7SivBEVY6x9jFY7oiqIPELPUroqVCNE_RQd0VpywaRcob86-BxdP2cXPA4Wr-cpRBixm6bZu7zFOeC8NnjPhXGHwMaBx9GEjduT3hq9153Heu30L-MTBptNxBvQ2nnYT29cXuPRbcyizmkZG_wu5QjFrqmUJxgyLvkG4rjFcGmeoycWxmReLP8xuvj86efZ1-r8-5dvZx_PK83bNle2ttIKPRAAI0UvuLaSQkdgaMq1atJw2bMBpOxsN3R80JYOvdACamg7Sxp2jN4ecq9j-D2blNXkkjbjCN6EOSnayqajnBTwzX_gVZijL7upmnBJJW9lgdgB0jGkFI1V19FNELeKErXrT93RX7FeLdFzP5nhn7MUVoDuAJSrhzjBTYjjoDJsxxBtBK9duitY5T-5uKcPuuz-7V4fAiwEBZex8Bc_akIFIXQHcHYLQurHTA</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Loon, Adriaan A.W.M. van</creator><creator>Kosman, Willeke</creator><creator>Zuilekorn, Hanneke I. van</creator><creator>Riet, Suzanne van</creator><creator>Frenken, Marijke</creator><creator>Schijns, Virgil E.J.C</creator><general>World Veterinary Poultry Association</general><general>Taylor & Francis Group</general><general>Taylor & Francis Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>20030201</creationdate><title>contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age</title><author>Loon, Adriaan A.W.M. van ; Kosman, Willeke ; Zuilekorn, Hanneke I. van ; Riet, Suzanne van ; Frenken, Marijke ; Schijns, Virgil E.J.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-f2f7f5cd0aae75b54cf71a90ad608020647b3da779f9d94dcf1db5c5a2a89f063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animal vaccines</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>B-lymphocytes</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - immunology</topic><topic>Bursa of Fabricius - immunology</topic><topic>cell-mediated immunity</topic><topic>chickens</topic><topic>Chickens - immunology</topic><topic>Chickens - virology</topic><topic>cyclophosphamide</topic><topic>Cyclophosphamide - pharmacology</topic><topic>humoral immunity</topic><topic>Immunity (Disease)</topic><topic>Infections</topic><topic>maternal immunity</topic><topic>monoclonal antibodies</topic><topic>Orthoreovirus, Avian - immunology</topic><topic>Poultry</topic><topic>Poultry Diseases - immunology</topic><topic>Poultry Diseases - prevention & control</topic><topic>Reoviridae</topic><topic>Reoviridae Infections - immunology</topic><topic>Reoviridae Infections - prevention & control</topic><topic>Reoviridae Infections - veterinary</topic><topic>vaccination</topic><topic>vaccines</topic><topic>Viral Vaccines - immunology</topic><topic>virulence</topic><topic>viruses</topic><topic>White Leghorn</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loon, Adriaan A.W.M. van</creatorcontrib><creatorcontrib>Kosman, Willeke</creatorcontrib><creatorcontrib>Zuilekorn, Hanneke I. van</creatorcontrib><creatorcontrib>Riet, Suzanne van</creatorcontrib><creatorcontrib>Frenken, Marijke</creatorcontrib><creatorcontrib>Schijns, Virgil E.J.C</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Avian pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loon, Adriaan A.W.M. van</au><au>Kosman, Willeke</au><au>Zuilekorn, Hanneke I. van</au><au>Riet, Suzanne van</au><au>Frenken, Marijke</au><au>Schijns, Virgil E.J.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age</atitle><jtitle>Avian pathology</jtitle><addtitle>Avian Pathol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>32</volume><issue>1</issue><spage>15</spage><epage>23</epage><pages>15-23</pages><issn>0307-9457</issn><eissn>1465-3338</eissn><abstract>The presence of maternal immunity in broilers does not preclude the successful protective immunization with an attenuated live reovirus vaccine at 1-day-old. This was recently demonstrated in a reovirus challenge model based on reovirus isolation from different organs (van Loon et al., 2002). Discrimination between challenge and vaccine virus was made by specific monoclonal antibody. Notably, at the day of challenge the levels of circulating reovirus-specific antibodies proved to be minimal or undetectable. This suggested an antibody-independent vaccination-induced immunity under the chosen conditions. In the present study we assessed the contribution of specific humoral responses in the same experimental model, by evaluating the control of a virulent challenge infection in the complete absence of B cells as a result of cyclophosphamide treatment. These experiments were performed in both SPF white leghorn chickens and commercially available broilers with passively acquired maternal antibodies. Our data demonstrate that the virus is controlled in the absence of actively produced antibodies, and is independent of B lymphocytes. This suggests that cellular immunity is sufficient for protection of broilers with maternal antibodies against reovirus infection following early age vaccination with live reoviral vaccine.</abstract><cop>England</cop><pub>World Veterinary Poultry Association</pub><pmid>12745377</pmid><doi>10.1080/0307945021000070679</doi><tpages>9</tpages></addata></record> |
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| ispartof | Avian pathology, 2003-02, Vol.32 (1), p.15-23 |
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| source | MEDLINE; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animal vaccines Animals Antibodies, Viral - blood Antibodies, Viral - immunology B-lymphocytes B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Bursa of Fabricius - immunology cell-mediated immunity chickens Chickens - immunology Chickens - virology cyclophosphamide Cyclophosphamide - pharmacology humoral immunity Immunity (Disease) Infections maternal immunity monoclonal antibodies Orthoreovirus, Avian - immunology Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Reoviridae Reoviridae Infections - immunology Reoviridae Infections - prevention & control Reoviridae Infections - veterinary vaccination vaccines Viral Vaccines - immunology virulence viruses White Leghorn |
| title | contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age |
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