Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury

This study was undertaken to evaluate the effect of simvastatin, a cholesterol-lowering agent, on the Akt-mediated signaling pathway and neurogenesis in the dentate gyrus (DG) of the hippocampus in rats after traumatic brain injury (TBI). Adult male Wistar rats were divided into three groups: (1) sh...

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Veröffentlicht in:	Journal of neurotrauma 2008-02, Vol.25 (2), p.130-139
Hauptverfasser:	Wu, Hongtao, Lu, Dunyue, Jiang, Hao, Xiong, Ye, Qu, Changsheng, Li, Bo, Mahmood, Asim, Zhou, Dong, Chopp, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites Blotting, Western Brain Brain Hemorrhage, Traumatic - drug therapy Brain Hemorrhage, Traumatic - pathology Brain Hemorrhage, Traumatic - physiopathology Brain research Brain-Derived Neurotrophic Factor - biosynthesis Bromodeoxyuridine Cell Proliferation - drug effects Complications and side effects Cyclic AMP Response Element-Binding Protein - biosynthesis Diagnosis Dosage and administration Drug therapy Enzymes Glycogen Synthase Kinase 3 - biosynthesis Head injuries Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Immunohistochemistry Injuries Male Maze Learning - drug effects Maze Learning - physiology Memory - drug effects Memory - physiology Memory, Disorders of Neurons - drug effects Neurons - physiology Neurosciences Oncogene Protein v-akt - physiology Phosphatidylinositol 3-Kinases - physiology Rats Rats, Wistar Risk factors Rodents Signal transduction Signal Transduction - physiology Simvastatin Simvastatin - pharmacology Statins Trauma Up-Regulation - drug effects Vascular Endothelial Growth Factor A - biosynthesis
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