MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

MAJOR histocompatibility complex class I molecules bind antigenic peptides in the endoplasmic reticulum (ER) and transport them to the cell surface for recognition by cytotoxic T lymphocytes. The peptides are predominantly generated from cytoplasmic proteins, probably by the action of the multicatal...

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Veröffentlicht in:	Nature (London) 1994-04, Vol.368 (6474), p.864-867
Hauptverfasser:	Ortmann, Bodo, Androlewicz, Matthew J., Cresswell, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Humanities and Social Sciences Immunity (Disease) letter Molecules multidisciplinary Science Science (multidisciplinary)
Online-Zugang:	Volltext
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