51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population
BackgroundLow levels of vitamin D have been widely reported in IBD with evidence suggesting a role in disease severity and treatment.AimIreland has high rates of vitamin D deficiency both in IBD and general populations. Studies investigating correlation of vitamin D deficiency and disease parameters...
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| Veröffentlicht in: | Gut 2017-04, Vol.66 (Suppl 1), p.A19 |
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| container_title | Gut |
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| creator | Jones, FM McCarthy, O Lavelle, A Twomey, P Mulcahy, H Cullen, G Sheridan, J Doherty, GA |
| description | BackgroundLow levels of vitamin D have been widely reported in IBD with evidence suggesting a role in disease severity and treatment.AimIreland has high rates of vitamin D deficiency both in IBD and general populations. Studies investigating correlation of vitamin D deficiency and disease parameters have been mixed.MethodWe conducted a single centre retrospective study in our hospital from Jan 2015- June 2016. The aim was to assess the prevalence of vitamin D deficiency in IBD and non-IBD cohorts and to assess the impact of vitamin D deficiency on disease activity in IBD. Patients were separated into 4 groups: Crohns Disease (CD), Ulcerative Colitis (UC), general gastroenterology (GI) and general medical (non-GI). Basic demographic data disease specific information was recorded. Vitamin D deficiency was defined as |
| doi_str_mv | 10.1136/gutjnl-2017-314127.51 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_bmj_p</sourceid><recordid>TN_cdi_proquest_journals_2043348500</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2043348500</sourcerecordid><originalsourceid>FETCH-LOGICAL-b690-b344b2e4508de4bbd6ceb9a296df6ea3e8704ee5a0fa92c72e59309a93de2613</originalsourceid><addsrcrecordid>eNo9kMtKxDAUhoMoOI4-ghBwo4uOufWSpc54GRhwobgNaXvqpLRNbVKH4saNL-qT2KHi6hw43_8f-BA6p2RBKY-u33pfNlXACI0DTgVl8SKkB2hGRZQEnCXJIZqR_TGMhTxGJ86VhJAkkXSGPkP68_X9aryuTYNXOIfCZAaabMBua3cONxZ3UGlvbOO2psXe4tw40A6wzrz5MH7AY1I32HTGbce9qHRda2-7Aad2B9U_f7m-XV3h1rb91HeKjgpdOTj7m3P0fH_3snwMNk8P6-XNJkgjSYKUC5EyECFJchBpmkcZpFIzGeVFBJpDEhMBEGpSaMmymEEoOZFa8hxYRPkcXUytbWffe3BelbbvmvGhYkRwLpKQkJEiE5XWpWo7U-tuUJSovWA1CVZ7wWoSrELKfwHt9HJz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2043348500</pqid></control><display><type>article</type><title>51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population</title><source>PubMed Central</source><creator>Jones, FM ; McCarthy, O ; Lavelle, A ; Twomey, P ; Mulcahy, H ; Cullen, G ; Sheridan, J ; Doherty, GA</creator><creatorcontrib>Jones, FM ; McCarthy, O ; Lavelle, A ; Twomey, P ; Mulcahy, H ; Cullen, G ; Sheridan, J ; Doherty, GA</creatorcontrib><description>BackgroundLow levels of vitamin D have been widely reported in IBD with evidence suggesting a role in disease severity and treatment.AimIreland has high rates of vitamin D deficiency both in IBD and general populations. Studies investigating correlation of vitamin D deficiency and disease parameters have been mixed.MethodWe conducted a single centre retrospective study in our hospital from Jan 2015- June 2016. The aim was to assess the prevalence of vitamin D deficiency in IBD and non-IBD cohorts and to assess the impact of vitamin D deficiency on disease activity in IBD. Patients were separated into 4 groups: Crohns Disease (CD), Ulcerative Colitis (UC), general gastroenterology (GI) and general medical (non-GI). Basic demographic data disease specific information was recorded. Vitamin D deficiency was defined as <30 nmol/L.Results395 patients were studied: 157 CD, 70 UC, 75 GI and 93 non-GI. IBD patients were found to have high rates of Vitamin D deficiency (33% levels<30 nmol/L). Serum Vitamin D did not differ significantly between groups with mean values of 44.9 nmol/L (CD), 50.7 nmol/L(UC), 45.4 nmol/L(GI) and 45.6 nmol/L(non-GI). Symptommatic IBD patients had significantly higher mean CRP levels (8.6 mg/L) versus those who were asymptomatic (3.5 mg/L), (p<0.001). 35% of IBD patients who were symptomatic had vitamin D deficiency compared with 27% of those who were asymptomatic.ConclusionsWe found very high rates of vitamin D deficiency in both IBD and non-IBD patients. Absolute levels did not differ significantly between groups. This may be accounted for by high overall prevalence of Vitamin D deficiency in this population or by confounders in the control population.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2017-314127.51</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Crohn's disease ; Gastroenterology ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestine ; Nutrient deficiency ; Patients ; Population studies ; Ulcerative colitis ; Vitamin D ; Vitamin deficiency</subject><ispartof>Gut, 2017-04, Vol.66 (Suppl 1), p.A19</ispartof><rights>2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2017 © 2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Jones, FM</creatorcontrib><creatorcontrib>McCarthy, O</creatorcontrib><creatorcontrib>Lavelle, A</creatorcontrib><creatorcontrib>Twomey, P</creatorcontrib><creatorcontrib>Mulcahy, H</creatorcontrib><creatorcontrib>Cullen, G</creatorcontrib><creatorcontrib>Sheridan, J</creatorcontrib><creatorcontrib>Doherty, GA</creatorcontrib><title>51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population</title><title>Gut</title><description>BackgroundLow levels of vitamin D have been widely reported in IBD with evidence suggesting a role in disease severity and treatment.AimIreland has high rates of vitamin D deficiency both in IBD and general populations. Studies investigating correlation of vitamin D deficiency and disease parameters have been mixed.MethodWe conducted a single centre retrospective study in our hospital from Jan 2015- June 2016. The aim was to assess the prevalence of vitamin D deficiency in IBD and non-IBD cohorts and to assess the impact of vitamin D deficiency on disease activity in IBD. Patients were separated into 4 groups: Crohns Disease (CD), Ulcerative Colitis (UC), general gastroenterology (GI) and general medical (non-GI). Basic demographic data disease specific information was recorded. Vitamin D deficiency was defined as <30 nmol/L.Results395 patients were studied: 157 CD, 70 UC, 75 GI and 93 non-GI. IBD patients were found to have high rates of Vitamin D deficiency (33% levels<30 nmol/L). Serum Vitamin D did not differ significantly between groups with mean values of 44.9 nmol/L (CD), 50.7 nmol/L(UC), 45.4 nmol/L(GI) and 45.6 nmol/L(non-GI). Symptommatic IBD patients had significantly higher mean CRP levels (8.6 mg/L) versus those who were asymptomatic (3.5 mg/L), (p<0.001). 35% of IBD patients who were symptomatic had vitamin D deficiency compared with 27% of those who were asymptomatic.ConclusionsWe found very high rates of vitamin D deficiency in both IBD and non-IBD patients. Absolute levels did not differ significantly between groups. This may be accounted for by high overall prevalence of Vitamin D deficiency in this population or by confounders in the control population.</description><subject>Crohn's disease</subject><subject>Gastroenterology</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Intestine</subject><subject>Nutrient deficiency</subject><subject>Patients</subject><subject>Population studies</subject><subject>Ulcerative colitis</subject><subject>Vitamin D</subject><subject>Vitamin deficiency</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNo9kMtKxDAUhoMoOI4-ghBwo4uOufWSpc54GRhwobgNaXvqpLRNbVKH4saNL-qT2KHi6hw43_8f-BA6p2RBKY-u33pfNlXACI0DTgVl8SKkB2hGRZQEnCXJIZqR_TGMhTxGJ86VhJAkkXSGPkP68_X9aryuTYNXOIfCZAaabMBua3cONxZ3UGlvbOO2psXe4tw40A6wzrz5MH7AY1I32HTGbce9qHRda2-7Aad2B9U_f7m-XV3h1rb91HeKjgpdOTj7m3P0fH_3snwMNk8P6-XNJkgjSYKUC5EyECFJchBpmkcZpFIzGeVFBJpDEhMBEGpSaMmymEEoOZFa8hxYRPkcXUytbWffe3BelbbvmvGhYkRwLpKQkJEiE5XWpWo7U-tuUJSovWA1CVZ7wWoSrELKfwHt9HJz</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Jones, FM</creator><creator>McCarthy, O</creator><creator>Lavelle, A</creator><creator>Twomey, P</creator><creator>Mulcahy, H</creator><creator>Cullen, G</creator><creator>Sheridan, J</creator><creator>Doherty, GA</creator><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201704</creationdate><title>51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population</title><author>Jones, FM ; McCarthy, O ; Lavelle, A ; Twomey, P ; Mulcahy, H ; Cullen, G ; Sheridan, J ; Doherty, GA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b690-b344b2e4508de4bbd6ceb9a296df6ea3e8704ee5a0fa92c72e59309a93de2613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Crohn's disease</topic><topic>Gastroenterology</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Intestine</topic><topic>Nutrient deficiency</topic><topic>Patients</topic><topic>Population studies</topic><topic>Ulcerative colitis</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, FM</creatorcontrib><creatorcontrib>McCarthy, O</creatorcontrib><creatorcontrib>Lavelle, A</creatorcontrib><creatorcontrib>Twomey, P</creatorcontrib><creatorcontrib>Mulcahy, H</creatorcontrib><creatorcontrib>Cullen, G</creatorcontrib><creatorcontrib>Sheridan, J</creatorcontrib><creatorcontrib>Doherty, GA</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, FM</au><au>McCarthy, O</au><au>Lavelle, A</au><au>Twomey, P</au><au>Mulcahy, H</au><au>Cullen, G</au><au>Sheridan, J</au><au>Doherty, GA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population</atitle><jtitle>Gut</jtitle><date>2017-04</date><risdate>2017</risdate><volume>66</volume><issue>Suppl 1</issue><spage>A19</spage><pages>A19-</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><abstract>BackgroundLow levels of vitamin D have been widely reported in IBD with evidence suggesting a role in disease severity and treatment.AimIreland has high rates of vitamin D deficiency both in IBD and general populations. Studies investigating correlation of vitamin D deficiency and disease parameters have been mixed.MethodWe conducted a single centre retrospective study in our hospital from Jan 2015- June 2016. The aim was to assess the prevalence of vitamin D deficiency in IBD and non-IBD cohorts and to assess the impact of vitamin D deficiency on disease activity in IBD. Patients were separated into 4 groups: Crohns Disease (CD), Ulcerative Colitis (UC), general gastroenterology (GI) and general medical (non-GI). Basic demographic data disease specific information was recorded. Vitamin D deficiency was defined as <30 nmol/L.Results395 patients were studied: 157 CD, 70 UC, 75 GI and 93 non-GI. IBD patients were found to have high rates of Vitamin D deficiency (33% levels<30 nmol/L). Serum Vitamin D did not differ significantly between groups with mean values of 44.9 nmol/L (CD), 50.7 nmol/L(UC), 45.4 nmol/L(GI) and 45.6 nmol/L(non-GI). Symptommatic IBD patients had significantly higher mean CRP levels (8.6 mg/L) versus those who were asymptomatic (3.5 mg/L), (p<0.001). 35% of IBD patients who were symptomatic had vitamin D deficiency compared with 27% of those who were asymptomatic.ConclusionsWe found very high rates of vitamin D deficiency in both IBD and non-IBD patients. Absolute levels did not differ significantly between groups. This may be accounted for by high overall prevalence of Vitamin D deficiency in this population or by confounders in the control population.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/gutjnl-2017-314127.51</doi></addata></record> |
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| subjects | Crohn's disease Gastroenterology Inflammatory bowel disease Inflammatory bowel diseases Intestine Nutrient deficiency Patients Population studies Ulcerative colitis Vitamin D Vitamin deficiency |
| title | 51 Vitamin D deficiency shows no relationship to disease activity in an irish inflammatory bowel disease (IBD) population |
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