Novel Conformation-Specific Antibodies Against Matrix γ-Carboxyglutamic Acid (Gla) Protein: Undercarboxylated Matrix Gla Protein as Marker for Vascular Calcification

OBJECTIVE—Matrix γ-carboxyglutamic acid (Gla) protein (MGP), a vitamin K–dependent protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascula...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2005-08, Vol.25 (8), p.1629-1633
Hauptverfasser:	Schurgers, Leon J, Teunissen, Kirsten J.F, Knapen, Marjo H.J, Kwaijtaal, Martijn, van Diest, Rob, Appels, Ad, Reutelingsperger, Chris P, Cleutjens, Jack P.M, Vermeer, Cees
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibody Specificity Associated diseases and complications Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism Atherosclerosis - pathology Biological and medical sciences Biomarkers - chemistry Biomarkers - metabolism Blood and lymphatic vessels Calcinosis - metabolism Calcinosis - pathology Calcium-Binding Proteins - blood Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - immunology Cardiology. Vascular system Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Emergency and intensive care: renal failure. Dialysis management Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epitopes - chemistry Epitopes - immunology Epitopes - metabolism Extracellular Matrix Proteins - blood Extracellular Matrix Proteins - chemistry Extracellular Matrix Proteins - immunology Humans Immunohistochemistry - methods Intensive care medicine Matrix Gla Protein Medical sciences Monckeberg Medial Calcific Sclerosis - metabolism Monckeberg Medial Calcific Sclerosis - pathology Protein Conformation Tunica Intima - metabolism Tunica Intima - pathology Tunica Media - metabolism Tunica Media - pathology Vitamin K - metabolism
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