Adipophilin Enhances Lipid Accumulation and Prevents Lipid Efflux From THP-1 Macrophages: Potential Role in Atherogenesis

OBJECTIVE—Uptake of modified low-density lipoprotein (LDL) by macrophages through scavenger receptors results in lipid droplets accumulation and foam cell formation. Excess lipid deposition in macrophages has been reported to modulate expression of several genes including adipophilin. In this study,...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-03, Vol.24 (3), p.504-510
Hauptverfasser:	Larigauderie, Guilhem, Furman, Christophe, Jaye, Michael, Lasselin, Catherine, Copin, Corinne, Fruchart, Jean-Charles, Castro, Graciela, Rouis, Mustapha
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoprotein A-I - pharmacology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Artery Diseases - etiology Carotid Artery Diseases - metabolism Carotid Artery Diseases - surgery Cell Differentiation - drug effects Cell Line - drug effects Cell Line - metabolism Cholesterol - metabolism Cholesterol Esters - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous DNA, Complementary - genetics Endarterectomy, Carotid Foam Cells - metabolism Gene Silencing Humans Lipid Metabolism Lipoproteins, LDL - pharmacology Macrophages - drug effects Macrophages - metabolism Medical sciences Membrane Proteins Monocytes - drug effects Peptides - genetics Peptides - physiology Perilipin-2 Receptors, Immunologic - metabolism Receptors, Scavenger RNA, Messenger - biosynthesis RNA, Small Interfering - pharmacology Tetradecanoylphorbol Acetate - pharmacology Transfection Triglycerides - metabolism
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