Synergistic Effect of Thrombin on Collagen-Induced Platelet Procoagulant Activity Is Mediated Through Protease-Activated Receptor-1

OBJECTIVE—In the blood coagulation process, the rate of thrombin formation is critically dependent on phosphatidylserine (PtdSer) at the surface of activated platelets. Thrombin synergistically enhances the collagen-induced platelet procoagulant response. The objective of this study is to elucidate...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2005-07, Vol.25 (7), p.1499-1505
Hauptverfasser:	Keuren, Jeffrey F.W, Wielders, Simone J.H, Ulrichts, Hans, Hackeng, Tilman, Heemskerk, Johan W.M, Deckmyn, Hans, Bevers, Edouard M, Lindhout, Theo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Calcium - pharmacokinetics Cardiology. Vascular system Collagen - metabolism Collagen - pharmacology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug Synergism Fundamental and applied biological sciences. Psychology General aspects Hemostatics - metabolism Hemostatics - pharmacology Humans In Vitro Techniques Medical sciences Molecular and cellular biology Platelet Platelet Glycoprotein GPIb-IX Complex - metabolism Platelet Membrane Glycoproteins - metabolism Receptor, PAR-1 - metabolism Thrombin - metabolism Thrombin - pharmacology Thromboplastin - metabolism Thrombosis - metabolism Vertebrates: cardiovascular system
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