Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures

Evidence has accumulated that Zn2+ plays a central role in neurodegenerative processes following brain injuries including ischaemia or epilepsy. In the present study, we examined patterns and possible mechanisms of Zn2+ neurotoxicity. Inclusion of 30–300 μm Zn2+ for 30 min caused neuronal necrosis a...

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Veröffentlicht in:	The European journal of neuroscience 1999-01, Vol.11 (1), p.327-334
Hauptverfasser:	Kim, Eun Young, Koh, Jae Young, Kim, Yang Hee, Sohn, Seonghyang, Joe, Eunhye, Gwag, Byoung Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Amino Acid Chloromethyl Ketones - pharmacology Animals Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - pharmacology Cell culture Cells, Cultured Cerebral Cortex - cytology Chromans - pharmacology cortical cell culture Cysteine Proteinase Inhibitors - pharmacology Dizocilpine Maleate - pharmacology Dopamine Agonists - pharmacology Drug Synergism Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Female Free radicals Free Radicals - metabolism Glucose Hypoglycemic Agents - pharmacology Insulin - pharmacology ischaemia Ischemia Kainic Acid - pharmacology Lipid Peroxidation - drug effects Mice Microscopy, Electron Mitochondrial Swelling Necrosis Nerve Degeneration - chemically induced Nerve Degeneration - metabolism Neurons - metabolism Neurons - pathology Neurons - ultrastructure Neurotoxicity Neurotoxins - pharmacology Oligopeptides - pharmacology Oxidative stress Oxidative Stress - drug effects Pregnancy zinc Zinc - pharmacokinetics Zinc - toxicity
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