Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Objective(s) High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (...

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Veröffentlicht in:European journal of endocrinology 2016-12, Vol.175 (6), p.531-540
Hauptverfasser: Zaharenko, Linda, Kalnina, Ineta, Geldnere, Kristine, Konrade, Ilze, Grinberga, Solveiga, Židzik, Jozef, Javorský, Martin, Lejnieks, Aivars, Nikitina-Zake, Liene, Fridmanis, Davids, Peculis, Raitis, Radovica-Spalvina, Ilze, Hartmane, Dace, Pugovics, Osvalds, Tkáč, Ivan, Klimčáková, Lucia, Pīrāgs, Valdis, Klovins, Janis
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Sprache:eng
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