Block effect on HCV infection by HMGB1 released from virus-infected cells: An insight from mathematical modeling
The nuclear protein high-mobility group box 1 (HMGB1) can have an active role in deoxyribonucleic acid (DNA) organization and the regulation of transcription. Based on the new findings from a recent experimental study, the blocking effect on HCV infection by HMGB1 released from virus-infected cells...
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| Veröffentlicht in: | Communications in nonlinear science & numerical simulation 2018-06, Vol.59, p.488-514 |
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| creator | Wang, Wei Ma, Wanbiao |
| description | The nuclear protein high-mobility group box 1 (HMGB1) can have an active role in deoxyribonucleic acid (DNA) organization and the regulation of transcription. Based on the new findings from a recent experimental study, the blocking effect on HCV infection by HMGB1 released from virus-infected cells is investigated using a diffusive model for viral infection dynamics. In the model, the diffusion of the virus depends not only on its concentration gradient, but also on the concentration of HMGB1. The basic reproduction number, threshold dynamics, stability properties of the steady states, travelling wave solutions, and spreading speed for the proposed model are studied. We show that the HMGB1-induced blocking of HCV infection slows the spread of virus compared with random diffusion only. Numerically, it is shown that a high concentration of HMGB1 can block the spread of virus and this confirms, not only qualitatively but also quantitatively, the experimental result. |
| doi_str_mv | 10.1016/j.cnsns.2017.11.024 |
| format | Article |
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Based on the new findings from a recent experimental study, the blocking effect on HCV infection by HMGB1 released from virus-infected cells is investigated using a diffusive model for viral infection dynamics. In the model, the diffusion of the virus depends not only on its concentration gradient, but also on the concentration of HMGB1. The basic reproduction number, threshold dynamics, stability properties of the steady states, travelling wave solutions, and spreading speed for the proposed model are studied. We show that the HMGB1-induced blocking of HCV infection slows the spread of virus compared with random diffusion only. 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Numerically, it is shown that a high concentration of HMGB1 can block the spread of virus and this confirms, not only qualitatively but also quantitatively, the experimental result.</description><subject>Basic reproduction number</subject><subject>Block effect</subject><subject>Blocking</subject><subject>Concentration gradient</subject><subject>Deoxyribonucleic acid</subject><subject>Diffusion rate</subject><subject>DNA</subject><subject>Dynamic stability</subject><subject>HCV</subject><subject>HMGB1</subject><subject>Mathematical models</subject><subject>Proteins</subject><subject>Spreading speed</subject><subject>Studies</subject><subject>Travelling wave solutions</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>1007-5704</issn><issn>1878-7274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEFPwyAUx4nRxDn9BF5IPLdCaaE18bAtupnMeFGvhNLXjdqWCd2SfXuZ9eyFx3v8_hB-CN1SElNC-X0T6973Pk4IFTGlMUnSMzShucgjkYj0POwJEVEmSHqJrrxvSEgVWTpBu3lr9ReGugY9YNvj1eITm_7UmdCVR7x6Xc4pdtCC8lDh2tkOH4zb-2jEwkxD2_oHPOtD0pvNdhipTg1bCIvRqsWdraA1_eYaXdSq9XDzV6fo4_npfbGK1m_Ll8VsHWnG6BDpvOIZB6oqRUETUSoGnBZVSpjgUNSVqpVQipa6BMYLlqVJwkWuwpGGlAGborvx3p2z33vwg2zs3vXhSZmQACc5z0ig2EhpZ713UMudM51yR0mJPKmVjfxVK09qJaUyqA2pxzEF4QMHA056baDXUBkXjMjKmn_zP8n9hC0</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Wang, Wei</creator><creator>Ma, Wanbiao</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201806</creationdate><title>Block effect on HCV infection by HMGB1 released from virus-infected cells: An insight from mathematical modeling</title><author>Wang, Wei ; Ma, Wanbiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-c8d656e1ada1ec07ba3e619d40376e9fdafa7aa1bcbe36935422678ae9fce43e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Basic reproduction number</topic><topic>Block effect</topic><topic>Blocking</topic><topic>Concentration gradient</topic><topic>Deoxyribonucleic acid</topic><topic>Diffusion rate</topic><topic>DNA</topic><topic>Dynamic stability</topic><topic>HCV</topic><topic>HMGB1</topic><topic>Mathematical models</topic><topic>Proteins</topic><topic>Spreading speed</topic><topic>Studies</topic><topic>Travelling wave solutions</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Ma, Wanbiao</creatorcontrib><collection>CrossRef</collection><jtitle>Communications in nonlinear science & numerical simulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wei</au><au>Ma, Wanbiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Block effect on HCV infection by HMGB1 released from virus-infected cells: An insight from mathematical modeling</atitle><jtitle>Communications in nonlinear science & numerical simulation</jtitle><date>2018-06</date><risdate>2018</risdate><volume>59</volume><spage>488</spage><epage>514</epage><pages>488-514</pages><issn>1007-5704</issn><eissn>1878-7274</eissn><abstract>The nuclear protein high-mobility group box 1 (HMGB1) can have an active role in deoxyribonucleic acid (DNA) organization and the regulation of transcription. 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| ispartof | Communications in nonlinear science & numerical simulation, 2018-06, Vol.59, p.488-514 |
| issn | 1007-5704 1878-7274 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Basic reproduction number Block effect Blocking Concentration gradient Deoxyribonucleic acid Diffusion rate DNA Dynamic stability HCV HMGB1 Mathematical models Proteins Spreading speed Studies Travelling wave solutions Viral infections Viruses |
| title | Block effect on HCV infection by HMGB1 released from virus-infected cells: An insight from mathematical modeling |
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