The aggregation potential of human amylin determines its cytotoxicity towards islet [beta]-cells

Human amylin is a small fibrillogenic protein that is the major constituent of pancreatic islet amyloid, which occurs in most subjects with type 2 diabetes. There is evidence that it can elicit in vitro apoptosis in islet Beta-cells, but the physical properties that underpin its cytotoxicity have no...

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Veröffentlicht in:	The FEBS journal 2006-08, Vol.273 (15), p.3614
Hauptverfasser:	Konarkowska, Barbara, Aitken, Jacqueline F, Kistler, Joerg, Zhang, Shaoping, Cooper, Garth J S
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cellular biology Diabetes Pancreas Proteins Scientific imaging Toxicity
Online-Zugang:	Volltext
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