MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS
Abstract The immune system must be tightly controlled not only to guarantee efficient protection from invading pathogens and oncogenic cells but also to avoid exaggerated immune responses and autoimmunity. This is achieved through interactions amongst leukocytes themselves, by signals from stromal c...
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| Veröffentlicht in: | Critical reviews in clinical laboratory sciences 2005, Vol.42 (1), p.71-104 |
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| creator | Tuckermann, Jan P. Kleiman, Anna McPherson, Kirsty G. Reichardt, Holger M. |
| description | Abstract
The immune system must be tightly controlled not only to guarantee efficient protection from invading pathogens and oncogenic cells but also to avoid exaggerated immune responses and autoimmunity. This is achieved through interactions amongst leukocytes themselves, by signals from stromal cells and also by various hormones, including glucocorticoids. The glucocorticoids are a class of steroid hormones that exert a wide range of anti-inflammatory and immunosuppressive activities after binding to the glucocorticoid receptor. The power of these hormones was acknowledged many decades ago, and today synthetic derivatives are widely used in the treatment of inflammatory disorders, autoimmunity and cancer. In this review, we summarize our present knowledge of the molecular mechanisms of glucocorticoid action, their influence on specific leukocytes and the induction of thymocyte apoptosis, with an emphasis on how molecular genetics has contributed to our growing, although still incomplete, understanding of these processes. |
| doi_str_mv | 10.1080/10408360590888983 |
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The immune system must be tightly controlled not only to guarantee efficient protection from invading pathogens and oncogenic cells but also to avoid exaggerated immune responses and autoimmunity. This is achieved through interactions amongst leukocytes themselves, by signals from stromal cells and also by various hormones, including glucocorticoids. The glucocorticoids are a class of steroid hormones that exert a wide range of anti-inflammatory and immunosuppressive activities after binding to the glucocorticoid receptor. The power of these hormones was acknowledged many decades ago, and today synthetic derivatives are widely used in the treatment of inflammatory disorders, autoimmunity and cancer. In this review, we summarize our present knowledge of the molecular mechanisms of glucocorticoid action, their influence on specific leukocytes and the induction of thymocyte apoptosis, with an emphasis on how molecular genetics has contributed to our growing, although still incomplete, understanding of these processes.</description><identifier>ISSN: 1040-8363</identifier><identifier>EISSN: 1549-781X</identifier><identifier>DOI: 10.1080/10408360590888983</identifier><identifier>PMID: 15697171</identifier><identifier>CODEN: CRCLBH</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents - metabolism ; Anti-Inflammatory Agents - therapeutic use ; apoptosis ; Apoptosis - drug effects ; Apoptosis - genetics ; dendritic cells ; glucocorticoids ; Glucocorticoids - metabolism ; Glucocorticoids - therapeutic use ; Humans ; immunosuppressants ; inflammation ; Inflammation - drug therapy ; Inflammation - genetics ; Inflammation - metabolism ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Receptors, Glucocorticoid - drug effects ; Receptors, Glucocorticoid - genetics ; Receptors, Glucocorticoid - metabolism ; thymocytes ; transcription</subject><ispartof>Critical reviews in clinical laboratory sciences, 2005, Vol.42 (1), p.71-104</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>Copyright CRC Press 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-249c3196f5ebc75c8e915a39eb15567070a612a2b8ec1196344d9e61796351143</citedby><cites>FETCH-LOGICAL-c431t-249c3196f5ebc75c8e915a39eb15567070a612a2b8ec1196344d9e61796351143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10408360590888983$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10408360590888983$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15697171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuckermann, Jan P.</creatorcontrib><creatorcontrib>Kleiman, Anna</creatorcontrib><creatorcontrib>McPherson, Kirsty G.</creatorcontrib><creatorcontrib>Reichardt, Holger M.</creatorcontrib><title>MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS</title><title>Critical reviews in clinical laboratory sciences</title><addtitle>Crit Rev Clin Lab Sci</addtitle><description>Abstract
The immune system must be tightly controlled not only to guarantee efficient protection from invading pathogens and oncogenic cells but also to avoid exaggerated immune responses and autoimmunity. This is achieved through interactions amongst leukocytes themselves, by signals from stromal cells and also by various hormones, including glucocorticoids. The glucocorticoids are a class of steroid hormones that exert a wide range of anti-inflammatory and immunosuppressive activities after binding to the glucocorticoid receptor. The power of these hormones was acknowledged many decades ago, and today synthetic derivatives are widely used in the treatment of inflammatory disorders, autoimmunity and cancer. In this review, we summarize our present knowledge of the molecular mechanisms of glucocorticoid action, their influence on specific leukocytes and the induction of thymocyte apoptosis, with an emphasis on how molecular genetics has contributed to our growing, although still incomplete, understanding of these processes.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>dendritic cells</subject><subject>glucocorticoids</subject><subject>Glucocorticoids - metabolism</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>immunosuppressants</subject><subject>inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - genetics</subject><subject>Inflammation - metabolism</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Receptors, Glucocorticoid - drug effects</subject><subject>Receptors, Glucocorticoid - genetics</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>thymocytes</subject><subject>transcription</subject><issn>1040-8363</issn><issn>1549-781X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kF-L00AUxQdR3HX1A_giwQffonMz_9GXkE23gSRTmhTcp2GaTtguabNOWmS_vbO0sKjo0z1wf-dw70HoPeDPgCX-AphiSThmCksplSQv0CUwqmIh4fvLoMM-DgC5QG-m6R5jzFlCX6MLYFwJEHCJTKXLPFuV6TKq8mye1kVTNZGeRTflKtOZXrZFpovrJirqqJ3nUabrdqnLJ6KoZ2VaVWlb6DpK6-uovK0Wc53dtnmULvSi1U3RvEWvejtM7t15XqHVLG-zeVzqmyJLy7ijBA5xQlVHQPGeuXUnWCedAmaJcmtgjAsssOWQ2GQtXQeBI5RulOMggmQAlFyhT6fcBz_-OLrpYHbbqXPDYPduPE6GC4oVpTiAH_8A78ej34fbTBLqEhyABAhOUOfHafKuNw9-u7P-0QA2T9Wbv6oPng_n4ON65zbPjnPXAfh2Arb7fvQ7-3P0w8Yc7OMw-t7bfbedDPlf_tff7HfODoe7znr3_MG_3b8AmB2ZSQ</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Tuckermann, Jan P.</creator><creator>Kleiman, Anna</creator><creator>McPherson, Kirsty G.</creator><creator>Reichardt, Holger M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS</title><author>Tuckermann, Jan P. ; Kleiman, Anna ; McPherson, Kirsty G. ; Reichardt, Holger M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-249c3196f5ebc75c8e915a39eb15567070a612a2b8ec1196344d9e61796351143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - metabolism</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>dendritic cells</topic><topic>glucocorticoids</topic><topic>Glucocorticoids - metabolism</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>immunosuppressants</topic><topic>inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - genetics</topic><topic>Inflammation - metabolism</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Receptors, Glucocorticoid - drug effects</topic><topic>Receptors, Glucocorticoid - genetics</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>thymocytes</topic><topic>transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuckermann, Jan P.</creatorcontrib><creatorcontrib>Kleiman, Anna</creatorcontrib><creatorcontrib>McPherson, Kirsty G.</creatorcontrib><creatorcontrib>Reichardt, Holger M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in clinical laboratory sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuckermann, Jan P.</au><au>Kleiman, Anna</au><au>McPherson, Kirsty G.</au><au>Reichardt, Holger M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS</atitle><jtitle>Critical reviews in clinical laboratory sciences</jtitle><addtitle>Crit Rev Clin Lab Sci</addtitle><date>2005</date><risdate>2005</risdate><volume>42</volume><issue>1</issue><spage>71</spage><epage>104</epage><pages>71-104</pages><issn>1040-8363</issn><eissn>1549-781X</eissn><coden>CRCLBH</coden><abstract>Abstract
The immune system must be tightly controlled not only to guarantee efficient protection from invading pathogens and oncogenic cells but also to avoid exaggerated immune responses and autoimmunity. This is achieved through interactions amongst leukocytes themselves, by signals from stromal cells and also by various hormones, including glucocorticoids. The glucocorticoids are a class of steroid hormones that exert a wide range of anti-inflammatory and immunosuppressive activities after binding to the glucocorticoid receptor. The power of these hormones was acknowledged many decades ago, and today synthetic derivatives are widely used in the treatment of inflammatory disorders, autoimmunity and cancer. In this review, we summarize our present knowledge of the molecular mechanisms of glucocorticoid action, their influence on specific leukocytes and the induction of thymocyte apoptosis, with an emphasis on how molecular genetics has contributed to our growing, although still incomplete, understanding of these processes.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>15697171</pmid><doi>10.1080/10408360590888983</doi><tpages>34</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - therapeutic use apoptosis Apoptosis - drug effects Apoptosis - genetics dendritic cells glucocorticoids Glucocorticoids - metabolism Glucocorticoids - therapeutic use Humans immunosuppressants inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - metabolism Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - pathology Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism thymocytes transcription |
| title | MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS |
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