sup 68^Ga-NOTA-Aca-BBN (7-14) PET imaging of GRPR in children with optic pathway gliomas
Objectives: Optic pathway glioma (OPG) is a rare neoplasm arising predominantly during childhood. Location in sensitive region involving optic pathways, onset in young patients, and controversial therapy choice make the management still a challenge in pediatric neuro-oncology. Long-term survival can...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2017-05, Vol.58, p.37 |
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| creator | Zhang, Jingjing Tian, Yongji Niu, Gang Li, Deling Lang, Lixin Li, Fang Zhu, Zhaohui Chen, Xiaoyuan |
| description | Objectives: Optic pathway glioma (OPG) is a rare neoplasm arising predominantly during childhood. Location in sensitive region involving optic pathways, onset in young patients, and controversial therapy choice make the management still a challenge in pediatric neuro-oncology. Long-term survival can be achieved in children with OPGs by using a tailored treatment in selected patients. However, there is a lack of optimal imaging surveillance or proper visualization of tumor biology at the molecular level of OPGs. This study aims to assess gastrin-releasing peptide receptor (GRPR) targeted PET imaging in children with OPG, also with 18F-FDG PET for comparison and PET/MRI imaging-guided surgery navigation platform application. Methods: Eight children (M 5, F 3, Age range 5-14y, mean age 8.81±4.64) with suspicious optic pathway gliomas, as diagnosed by contrast-enhanced MRI were recruited. Written informed consent was obtained from all patients and legal guardians. Brain PET/CT or PET/MRI acquisitions were performed at 30 min after bolus injection of 68Ga-NOTA-Aca-BBN(7-14) (33.3-90.7 MBq, 1.85 MBq per kilogram of body weight). 4 patients also accepted 18F-FDG brain PET/CT for comparison within 3 days. Regions of interest (ROIs) were drawn manually on the brain lesions using 3D ellipsoid isocontour on each image with the assistance of the corresponding CT and MRI images by two experienced nuclear medicine physicians. Visual assessment and semi-quantitative analysis using SUVmean and SUVmax were used. All the patients underwent surgical removal within 1 week with 68Ga-NOTA-Aca-BBN(7-14) PET-MRI image fusion and navigation platform. After surgical removal, Immunohistochemical staining of tumor samples against GRPR was performed and correlated with 68Ga-NOTA-Aca-BBN(7-14) PET. Results: All 11 lesions in the 8 patients showed prominent 68Ga-NOTA-Aca-BBN(7-14) probe accumulation with excellent contrast to surrounding normal brain tissue. The SUVmax and SUVmean of all the lesions (n = 11) were 1.82 ± 0.59 and 1.17 ± 0.47, respectively. Tumor-to-background ratios were 28.4 ± 5.59 and 18.3 ± 4.99 based on SUVmax and SUVmean, respectively. The SUVmean and SUVmax on 18F-FDG were calculated to be 4.83 ± 1.51 and 7.92 ± 2.08, respectively. 68Ga-NOTA-Aca-BBN(7-14) showed much better tumor/background ratio (28.4 ± 5.59) over 18F-FDG (0.60 ± 0.07). Fusion images were obtained in all cases successfully in PET-MRI navigation platform for tumor delineation. All lesions were conf |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_2039865564</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2039865564</sourcerecordid><originalsourceid>FETCH-proquest_journals_20398655643</originalsourceid><addsrcrecordid>eNqNyrsOgjAYQOHGaCJe3uFPXHRoUoTWOqJRnNQQBidJg1xqoK0UQnx7HXwApzN8Z4Acl3oUU8Y2Q-QQl7mYUkLHaGLtkxDCOOcOutnOAOP3UODzJQ5wkAq8251hucGuv4LrIQZZi0KqAnQOYXSNQCpIS1k9mkxBL9sStGllCka0ZS_eUFRS18LO0CgXlc3mv07R4niI9ydsGv3qMtsmT9016kvJmnhbzihlvvff9QEqID84</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2039865564</pqid></control><display><type>article</type><title>sup 68^Ga-NOTA-Aca-BBN (7-14) PET imaging of GRPR in children with optic pathway gliomas</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Zhang, Jingjing ; Tian, Yongji ; Niu, Gang ; Li, Deling ; Lang, Lixin ; Li, Fang ; Zhu, Zhaohui ; Chen, Xiaoyuan</creator><creatorcontrib>Zhang, Jingjing ; Tian, Yongji ; Niu, Gang ; Li, Deling ; Lang, Lixin ; Li, Fang ; Zhu, Zhaohui ; Chen, Xiaoyuan</creatorcontrib><description>Objectives: Optic pathway glioma (OPG) is a rare neoplasm arising predominantly during childhood. Location in sensitive region involving optic pathways, onset in young patients, and controversial therapy choice make the management still a challenge in pediatric neuro-oncology. Long-term survival can be achieved in children with OPGs by using a tailored treatment in selected patients. However, there is a lack of optimal imaging surveillance or proper visualization of tumor biology at the molecular level of OPGs. This study aims to assess gastrin-releasing peptide receptor (GRPR) targeted PET imaging in children with OPG, also with 18F-FDG PET for comparison and PET/MRI imaging-guided surgery navigation platform application. Methods: Eight children (M 5, F 3, Age range 5-14y, mean age 8.81±4.64) with suspicious optic pathway gliomas, as diagnosed by contrast-enhanced MRI were recruited. Written informed consent was obtained from all patients and legal guardians. Brain PET/CT or PET/MRI acquisitions were performed at 30 min after bolus injection of 68Ga-NOTA-Aca-BBN(7-14) (33.3-90.7 MBq, 1.85 MBq per kilogram of body weight). 4 patients also accepted 18F-FDG brain PET/CT for comparison within 3 days. Regions of interest (ROIs) were drawn manually on the brain lesions using 3D ellipsoid isocontour on each image with the assistance of the corresponding CT and MRI images by two experienced nuclear medicine physicians. Visual assessment and semi-quantitative analysis using SUVmean and SUVmax were used. All the patients underwent surgical removal within 1 week with 68Ga-NOTA-Aca-BBN(7-14) PET-MRI image fusion and navigation platform. After surgical removal, Immunohistochemical staining of tumor samples against GRPR was performed and correlated with 68Ga-NOTA-Aca-BBN(7-14) PET. Results: All 11 lesions in the 8 patients showed prominent 68Ga-NOTA-Aca-BBN(7-14) probe accumulation with excellent contrast to surrounding normal brain tissue. The SUVmax and SUVmean of all the lesions (n = 11) were 1.82 ± 0.59 and 1.17 ± 0.47, respectively. Tumor-to-background ratios were 28.4 ± 5.59 and 18.3 ± 4.99 based on SUVmax and SUVmean, respectively. The SUVmean and SUVmax on 18F-FDG were calculated to be 4.83 ± 1.51 and 7.92 ± 2.08, respectively. 68Ga-NOTA-Aca-BBN(7-14) showed much better tumor/background ratio (28.4 ± 5.59) over 18F-FDG (0.60 ± 0.07). Fusion images were obtained in all cases successfully in PET-MRI navigation platform for tumor delineation. All lesions were confirmed as optic pathway gliomas by the final pathological evaluation. Among them, 6 patients were diagnosed as pilocytic astrocytoma WHO grade I, and the other 2 patients as WHO grade II. The immunohistochemical staining result showed positive GRPR expression in all 11 samples from 8 patients. There was significant positive correlation between SUV from 68Ga-NOTA-Aca-BBN(7-14) and expression level of GRPR (r2 = 0.56, P < 0.01 for SUVmax and r2 = 0.47, P < 0.05 for SUVmean, respectively). Conclusion: This prospective study indicates the feasibility of 68Ga-NOTA-Aca-BBN(7-14) PET in children with OPG for tumor detection, localization and differentiation. GRPR PET has the potential to provid imaging guidance for further GRPR targeted therapy in children with OPG. Research Support: Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><language>eng</language><publisher>New York: Society of Nuclear Medicine</publisher><subject>Astrocytoma ; Bioengineering ; Body weight ; Brain ; Children ; Children & youth ; Computed tomography ; Computer vision ; Drug delivery systems ; Eyes & eyesight ; Feasibility studies ; Fluorine isotopes ; Gastrin ; Gastrin-releasing peptide ; Glioma ; Image processing ; Informed consent ; Lesions ; Localization ; Magnetic resonance imaging ; Medical imaging ; Medical personnel ; Neoplasia ; Neuroimaging ; Nuclear medicine ; Oncology ; Patients ; Physicians ; Positron emission ; Positron emission tomography ; Quantitative analysis ; Staining ; Surgery ; Therapy ; Tomography ; Tumors ; Visual pathways</subject><ispartof>The Journal of nuclear medicine (1978), 2017-05, Vol.58, p.37</ispartof><rights>Copyright Society of Nuclear Medicine May 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Zhang, Jingjing</creatorcontrib><creatorcontrib>Tian, Yongji</creatorcontrib><creatorcontrib>Niu, Gang</creatorcontrib><creatorcontrib>Li, Deling</creatorcontrib><creatorcontrib>Lang, Lixin</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Zhu, Zhaohui</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><title>sup 68^Ga-NOTA-Aca-BBN (7-14) PET imaging of GRPR in children with optic pathway gliomas</title><title>The Journal of nuclear medicine (1978)</title><description>Objectives: Optic pathway glioma (OPG) is a rare neoplasm arising predominantly during childhood. Location in sensitive region involving optic pathways, onset in young patients, and controversial therapy choice make the management still a challenge in pediatric neuro-oncology. Long-term survival can be achieved in children with OPGs by using a tailored treatment in selected patients. However, there is a lack of optimal imaging surveillance or proper visualization of tumor biology at the molecular level of OPGs. This study aims to assess gastrin-releasing peptide receptor (GRPR) targeted PET imaging in children with OPG, also with 18F-FDG PET for comparison and PET/MRI imaging-guided surgery navigation platform application. Methods: Eight children (M 5, F 3, Age range 5-14y, mean age 8.81±4.64) with suspicious optic pathway gliomas, as diagnosed by contrast-enhanced MRI were recruited. Written informed consent was obtained from all patients and legal guardians. Brain PET/CT or PET/MRI acquisitions were performed at 30 min after bolus injection of 68Ga-NOTA-Aca-BBN(7-14) (33.3-90.7 MBq, 1.85 MBq per kilogram of body weight). 4 patients also accepted 18F-FDG brain PET/CT for comparison within 3 days. Regions of interest (ROIs) were drawn manually on the brain lesions using 3D ellipsoid isocontour on each image with the assistance of the corresponding CT and MRI images by two experienced nuclear medicine physicians. Visual assessment and semi-quantitative analysis using SUVmean and SUVmax were used. All the patients underwent surgical removal within 1 week with 68Ga-NOTA-Aca-BBN(7-14) PET-MRI image fusion and navigation platform. After surgical removal, Immunohistochemical staining of tumor samples against GRPR was performed and correlated with 68Ga-NOTA-Aca-BBN(7-14) PET. Results: All 11 lesions in the 8 patients showed prominent 68Ga-NOTA-Aca-BBN(7-14) probe accumulation with excellent contrast to surrounding normal brain tissue. The SUVmax and SUVmean of all the lesions (n = 11) were 1.82 ± 0.59 and 1.17 ± 0.47, respectively. Tumor-to-background ratios were 28.4 ± 5.59 and 18.3 ± 4.99 based on SUVmax and SUVmean, respectively. The SUVmean and SUVmax on 18F-FDG were calculated to be 4.83 ± 1.51 and 7.92 ± 2.08, respectively. 68Ga-NOTA-Aca-BBN(7-14) showed much better tumor/background ratio (28.4 ± 5.59) over 18F-FDG (0.60 ± 0.07). Fusion images were obtained in all cases successfully in PET-MRI navigation platform for tumor delineation. All lesions were confirmed as optic pathway gliomas by the final pathological evaluation. Among them, 6 patients were diagnosed as pilocytic astrocytoma WHO grade I, and the other 2 patients as WHO grade II. The immunohistochemical staining result showed positive GRPR expression in all 11 samples from 8 patients. There was significant positive correlation between SUV from 68Ga-NOTA-Aca-BBN(7-14) and expression level of GRPR (r2 = 0.56, P < 0.01 for SUVmax and r2 = 0.47, P < 0.05 for SUVmean, respectively). Conclusion: This prospective study indicates the feasibility of 68Ga-NOTA-Aca-BBN(7-14) PET in children with OPG for tumor detection, localization and differentiation. GRPR PET has the potential to provid imaging guidance for further GRPR targeted therapy in children with OPG. Research Support: Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)</description><subject>Astrocytoma</subject><subject>Bioengineering</subject><subject>Body weight</subject><subject>Brain</subject><subject>Children</subject><subject>Children & youth</subject><subject>Computed tomography</subject><subject>Computer vision</subject><subject>Drug delivery systems</subject><subject>Eyes & eyesight</subject><subject>Feasibility studies</subject><subject>Fluorine isotopes</subject><subject>Gastrin</subject><subject>Gastrin-releasing peptide</subject><subject>Glioma</subject><subject>Image processing</subject><subject>Informed consent</subject><subject>Lesions</subject><subject>Localization</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Medical personnel</subject><subject>Neoplasia</subject><subject>Neuroimaging</subject><subject>Nuclear medicine</subject><subject>Oncology</subject><subject>Patients</subject><subject>Physicians</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Quantitative analysis</subject><subject>Staining</subject><subject>Surgery</subject><subject>Therapy</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Visual pathways</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNyrsOgjAYQOHGaCJe3uFPXHRoUoTWOqJRnNQQBidJg1xqoK0UQnx7HXwApzN8Z4Acl3oUU8Y2Q-QQl7mYUkLHaGLtkxDCOOcOutnOAOP3UODzJQ5wkAq8251hucGuv4LrIQZZi0KqAnQOYXSNQCpIS1k9mkxBL9sStGllCka0ZS_eUFRS18LO0CgXlc3mv07R4niI9ydsGv3qMtsmT9016kvJmnhbzihlvvff9QEqID84</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Zhang, Jingjing</creator><creator>Tian, Yongji</creator><creator>Niu, Gang</creator><creator>Li, Deling</creator><creator>Lang, Lixin</creator><creator>Li, Fang</creator><creator>Zhu, Zhaohui</creator><creator>Chen, Xiaoyuan</creator><general>Society of Nuclear Medicine</general><scope>4T-</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20170501</creationdate><title>sup 68^Ga-NOTA-Aca-BBN (7-14) PET imaging of GRPR in children with optic pathway gliomas</title><author>Zhang, Jingjing ; Tian, Yongji ; Niu, Gang ; Li, Deling ; Lang, Lixin ; Li, Fang ; Zhu, Zhaohui ; Chen, Xiaoyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_20398655643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Astrocytoma</topic><topic>Bioengineering</topic><topic>Body weight</topic><topic>Brain</topic><topic>Children</topic><topic>Children & youth</topic><topic>Computed tomography</topic><topic>Computer vision</topic><topic>Drug delivery systems</topic><topic>Eyes & eyesight</topic><topic>Feasibility studies</topic><topic>Fluorine isotopes</topic><topic>Gastrin</topic><topic>Gastrin-releasing peptide</topic><topic>Glioma</topic><topic>Image processing</topic><topic>Informed consent</topic><topic>Lesions</topic><topic>Localization</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Medical personnel</topic><topic>Neoplasia</topic><topic>Neuroimaging</topic><topic>Nuclear medicine</topic><topic>Oncology</topic><topic>Patients</topic><topic>Physicians</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Quantitative analysis</topic><topic>Staining</topic><topic>Surgery</topic><topic>Therapy</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Visual pathways</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jingjing</creatorcontrib><creatorcontrib>Tian, Yongji</creatorcontrib><creatorcontrib>Niu, Gang</creatorcontrib><creatorcontrib>Li, Deling</creatorcontrib><creatorcontrib>Lang, Lixin</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Zhu, Zhaohui</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><collection>Docstoc</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jingjing</au><au>Tian, Yongji</au><au>Niu, Gang</au><au>Li, Deling</au><au>Lang, Lixin</au><au>Li, Fang</au><au>Zhu, Zhaohui</au><au>Chen, Xiaoyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>sup 68^Ga-NOTA-Aca-BBN (7-14) PET imaging of GRPR in children with optic pathway gliomas</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><date>2017-05-01</date><risdate>2017</risdate><volume>58</volume><spage>37</spage><pages>37-</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Objectives: Optic pathway glioma (OPG) is a rare neoplasm arising predominantly during childhood. Location in sensitive region involving optic pathways, onset in young patients, and controversial therapy choice make the management still a challenge in pediatric neuro-oncology. Long-term survival can be achieved in children with OPGs by using a tailored treatment in selected patients. However, there is a lack of optimal imaging surveillance or proper visualization of tumor biology at the molecular level of OPGs. This study aims to assess gastrin-releasing peptide receptor (GRPR) targeted PET imaging in children with OPG, also with 18F-FDG PET for comparison and PET/MRI imaging-guided surgery navigation platform application. Methods: Eight children (M 5, F 3, Age range 5-14y, mean age 8.81±4.64) with suspicious optic pathway gliomas, as diagnosed by contrast-enhanced MRI were recruited. Written informed consent was obtained from all patients and legal guardians. Brain PET/CT or PET/MRI acquisitions were performed at 30 min after bolus injection of 68Ga-NOTA-Aca-BBN(7-14) (33.3-90.7 MBq, 1.85 MBq per kilogram of body weight). 4 patients also accepted 18F-FDG brain PET/CT for comparison within 3 days. Regions of interest (ROIs) were drawn manually on the brain lesions using 3D ellipsoid isocontour on each image with the assistance of the corresponding CT and MRI images by two experienced nuclear medicine physicians. Visual assessment and semi-quantitative analysis using SUVmean and SUVmax were used. All the patients underwent surgical removal within 1 week with 68Ga-NOTA-Aca-BBN(7-14) PET-MRI image fusion and navigation platform. After surgical removal, Immunohistochemical staining of tumor samples against GRPR was performed and correlated with 68Ga-NOTA-Aca-BBN(7-14) PET. Results: All 11 lesions in the 8 patients showed prominent 68Ga-NOTA-Aca-BBN(7-14) probe accumulation with excellent contrast to surrounding normal brain tissue. The SUVmax and SUVmean of all the lesions (n = 11) were 1.82 ± 0.59 and 1.17 ± 0.47, respectively. Tumor-to-background ratios were 28.4 ± 5.59 and 18.3 ± 4.99 based on SUVmax and SUVmean, respectively. The SUVmean and SUVmax on 18F-FDG were calculated to be 4.83 ± 1.51 and 7.92 ± 2.08, respectively. 68Ga-NOTA-Aca-BBN(7-14) showed much better tumor/background ratio (28.4 ± 5.59) over 18F-FDG (0.60 ± 0.07). Fusion images were obtained in all cases successfully in PET-MRI navigation platform for tumor delineation. All lesions were confirmed as optic pathway gliomas by the final pathological evaluation. Among them, 6 patients were diagnosed as pilocytic astrocytoma WHO grade I, and the other 2 patients as WHO grade II. The immunohistochemical staining result showed positive GRPR expression in all 11 samples from 8 patients. There was significant positive correlation between SUV from 68Ga-NOTA-Aca-BBN(7-14) and expression level of GRPR (r2 = 0.56, P < 0.01 for SUVmax and r2 = 0.47, P < 0.05 for SUVmean, respectively). Conclusion: This prospective study indicates the feasibility of 68Ga-NOTA-Aca-BBN(7-14) PET in children with OPG for tumor detection, localization and differentiation. GRPR PET has the potential to provid imaging guidance for further GRPR targeted therapy in children with OPG. Research Support: Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)</abstract><cop>New York</cop><pub>Society of Nuclear Medicine</pub></addata></record> |
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| subjects | Astrocytoma Bioengineering Body weight Brain Children Children & youth Computed tomography Computer vision Drug delivery systems Eyes & eyesight Feasibility studies Fluorine isotopes Gastrin Gastrin-releasing peptide Glioma Image processing Informed consent Lesions Localization Magnetic resonance imaging Medical imaging Medical personnel Neoplasia Neuroimaging Nuclear medicine Oncology Patients Physicians Positron emission Positron emission tomography Quantitative analysis Staining Surgery Therapy Tomography Tumors Visual pathways |
| title | sup 68^Ga-NOTA-Aca-BBN (7-14) PET imaging of GRPR in children with optic pathway gliomas |
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