Near-Infrared Fluorescence Bombesin Antagonist Peptides for Molecular Imaging of Prostate Cancer

Objectives: We aimed to develop near-infrared fluorescent (NIRF) bombesin antagonist peptides to target the gastrin releasing peptide receptors (GRPRs) overexpressed in human prostate cancers. Methods: Alexa fluor 750 was conjugated to -DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2, with a spacer Gly-4am...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2017-05, Vol.58, p.262
Hauptverfasser:	Xu, Hang, Bandari, Rajendra, Jiang, Zongrun, Smith, Charles, Lee, Li, Yu, Ping, Hoffman, Timothy, Ma, Lixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Binding Bombesin Cells Chemical synthesis Coinjection Fluorescence Gastrin High-performance liquid chromatography I.R. radiation Imaging In vivo methods and tests Injection Liquid chromatography Molecular weight Mouse devices Muscles Nuclear medicine Peptides Piperidine Prostate cancer Receptors Rodents Spacer Tumors
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