Drug Insight: vascular disrupting agents and angiogenesis—novel approaches for drug delivery

Vascular disrupting agents (VDAs) are designed to disrupt the already established abnormal vasculature, and induce rapid shutdown of tumor blood supply causing subsequent tumor death from hypoxia and nutrient deprivation. The authors discuss the strategies to improve drug delivery, and suggest that...

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Veröffentlicht in:	Nature clinical practice. Oncology 2006-12, Vol.3 (12), p.682-692
Hauptverfasser:	Cooney, Matthew M, van Heeckeren, Willem, Bhakta, Shyam, Ortiz, Jose, Remick, Scot C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - pharmacokinetics Angiogenesis Inhibitors - pharmacology Bevacizumab Blood pressure Cardiovascular agents Cell survival Chemotherapy Clinical trials Control Cytotoxicity Dosage and administration Drug delivery Drug Delivery Systems Drug development Endothelial cells Endothelium Endothelium, Vascular - drug effects Heart rate Humans Hypoxia Medicine Medicine & Public Health Monoclonal antibodies Neoplasms - blood supply Neoplasms - drug therapy Neovascularization Neovascularization, Pathologic Neuropathy Oncology Permeability Physiological aspects Protein-tyrosine kinase Radiation therapy review-article Targeted cancer therapy Tumors Ventricle
Online-Zugang:	Volltext
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