PTH-020 Factors Influencing Abnormal Gland Morphogenesis in Colorectal Cancer (CRC) - Translational Studies

Introduction Disruption of colorectal gland formation characterises high grade, aggressive CRCs but causal mechanisms remain unclear. Glandular morphogenesis can be modelled in three-dimensional (3D) culture systems that enable investigation of specific oncogenic signals. We have shown that the tumo...

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Veröffentlicht in:	Gut 2013-06, Vol.62 (Suppl 1), p.A219-A219
Hauptverfasser:	Topley, R, Fatehullah, A, Deevi, R, Jagan, I, Eves, J, Loughrey, M, Arthur, K, Stevenson, M, Campbell, F C
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Cdc42 protein Cell culture Cell membranes Colorectal cancer Colorectal carcinoma Confocal microscopy Cytology Guanine Guanine nucleotide exchange factor Guanine nucleotide-binding protein Guanosine triphosphatases Investigations Localization Morphogenesis Morphology Parathyroid hormone Phenotypes PTEN protein Signal transduction Transfection Tumors
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