PTH-008 Photodynamic Antimicrobial Chemotherapy (PACT) Selectively Kills Clostridium Difficile over Colon Cells and is Effective Against 5 Hypervirulent Strains of the Pathogen

IntroductionClostridium difficile (CD) is the leading cause of hospital and community-acquired antibiotic-associated diarrhoea in the developed world. Since 2003, a new lineage of strains with more severe virulence has emerged, leading to an increased number of outbreaks of disease in North America...

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Veröffentlicht in:	Gut 2013-06, Vol.62 (Suppl 1), p.A215-A215
Hauptverfasser:	Butt, M A, Sordi, L De, Yahioglu, G, Moose, C, Battah, S, Stamati, I, Deonarain, M, Mullany, P, Allan, E, Lovat, L B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobic conditions Anaerobic conditions Chemotherapy Colitis Colon Cytotoxicity Diarrhea Drug development Drug dosages High-throughput screening Mimicry Outbreaks Parathyroid hormone Pathogens Reactive oxygen species Strains (organisms) Virulence
Online-Zugang:	Volltext
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