PWE-087 Interleukin-17a Homodimer Reduces Pro-inflammatory Cytokine Production By Inflammatory Bowel Disease Mucosa Cultured Ex Vivo

Introduction Interleukin (IL)-17A, which is up-regulated in inflammatory bowel disease (IBD) mucosal lesions, and IL-17F are normally present as IL-17AA and IL-17FF homodimers and may occasionally form IL-17A/F heterodimers. The role of each IL-17 dimer in IBD is currently unknown. Therefore, we stu...

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Veröffentlicht in:	Gut 2014-06, Vol.63 (Suppl 1), p.A162-A162
Hauptverfasser:	Biancheri, P, Di Sabatino, A, Curciarello, R, Corazza, GR, Lindsay, JO, MacDonald, TT
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Cell culture Colon Crohn's disease Cytokines Enzyme-linked immunosorbent assay Inflammatory bowel disease Inflammatory bowel diseases Interleukin 17 Interleukin 6 Interleukin 8 Intestine Mucosa Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Ulcerative colitis
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