PWE-111 Higher Red Blood Cell Methotrexate Polyglutamates Correlate With Increased Disease Activity, And Are Useful In Assessing Adherence

Introduction Methotrexate (MTX) is commonly used in patients with inflammatory bowel disease (IBD). Within red blood cells (RBC), MTX is activated by sequential addition of glutamic acid residues to form polyglutamates (MTXPG 1–5). In rheumatoid arthritis, low [MTXPG] has been associated with active...

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Veröffentlicht in:	Gut 2014-06, Vol.63 (Suppl 1), p.A173
Hauptverfasser:	Fong, S, Ward, MG, Nasr, I, Goel, RM, Patel, KV, Ray, S, Arenas Hernandez, M, Anderson, SA, Marinaki, T, Sanderson, JD, Irving, PM
Format:	Artikel
Sprache:	eng
Schlagworte:	C-reactive protein Clinical trials Colitis Endoscopy Erythrocytes Glutamic acid High-performance liquid chromatography Inflammatory bowel disease Inflammatory bowel diseases Intestine Methotrexate Remission Rheumatoid arthritis
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