Pharmacokinetics and metabolite identification study of flavonoid dimer FD18: A potent P-glycoprotein modulator in reversing cancer drug resistance

Overexpression of P-glycoprotein (P-gp) is one of the leading causes of multidrug resistance in chemotherapy. P-gp reduces the intracellular drug concentration below their respective therapeutic level. To reverse P-gp mediated drug resistance, we recently reported that synthetic flavonoid dimer is a...

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