First-in-human phase I dose escalation study of the Bromodomain and Extra-Terminal motif (BET) inhibitor BAY 1238097 in subjects with advanced malignancies

Background: BET proteins play an essential role in regulation of transcription of genes involved in cell proliferation and survival, including oncogenes such as MYC. BAY 1238097, a potent highly selective inhibitor of BET proteins suppresses MYC expression and inhibits tumor growth in preclinical mo...

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Veröffentlicht in:	European journal of cancer (1990) 2016-12, Vol.69, p.S7-S8
Hauptverfasser:	Postel-Vinay, S, Herbschleb, K, Massard, C, Woodcock, V, Ocker, M, Wilkinson, G, Walter, A, Ewerton, F, Poelman, M, Middleton, M, Soria, J.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Back pain Biomarkers Blood levels Cancer Cell proliferation Cell survival Clinical trials Dosage Gene expression Gene regulation Headache Hematology, Oncology and Palliative Medicine Inhibitors Ischemia Lymphoma Modulation Myc protein Narcotics Nausea Opioids Pain Patients Pharmacokinetics Pharmacology Prescription drugs Proteins Solid tumors Stroke Thromboembolism Toxicity Transcription Transcription factors Tumors Vomiting
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