0899 Determinants of Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease and Concomitant Obstructive Sleep Apnea: the COPD-OSA Overlap Syndrome
Abstract Introduction In chronic obstructive pulmonary disease (COPD) patients without associated obstructive sleep apnea (OSA) quantitative measurements of sleep quality appear to be related to the severity of obstructive airways disease and nocturnal oxygenation. However, the determinants of sleep...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A334-A334 |
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| creator | Krachman, S Jaffe, F Soler, X Chatila, W D’alonzo, G E Weaver, S Bakhsh, K Dhesi, S Shariff, T Criner, G Vega-Sanchez, M |
| description | Abstract
Introduction
In chronic obstructive pulmonary disease (COPD) patients without associated obstructive sleep apnea (OSA) quantitative measurements of sleep quality appear to be related to the severity of obstructive airways disease and nocturnal oxygenation. However, the determinants of sleep quality in patients with COPD-OSA overlap syndrome are unknown. We hypothesize that both parameters of airflow obstruction and severity of OSA contribute to the sleep quality in COPD-OSA overlap syndrome.
Methods
Participants were derived from the COPDGene project. The study included patients who underwent a full night polysomnogram (PSG) and where diagnosed with OSA (AHI≥ 5 events/hr). To confirm the presence of COPD, and prior to the PSG, patients had spirometry performed, and obtained a chest computed tomography (CT) for measurements of percent emphysema and gas trapping.
Results
Twenty-one patients [10 (48%) males, 57 ± 8 years/old, FEV1 1.2 ± 0.5 L, FEV1 %Predicted 45 ± 19%, FVC 2.3 ± 0.7 L, FVC %Predicted 68 ± 20%, FEV1/FVC 50 ± 11%, BMI 34 ± 9 kg/m2)] were diagnosed with OSA (apnea-hypopnea index [AHI] 16 ± 12 events/hour). The total sleep time (TST) was 286 ± 86 minutes with a sleep efficiency (SE) of 67 ± 23%.The Arousal index (AI) was 26 ± 27 arousals/hr. The mean SaO2 was 93 ± 3% with the lowest SaO2 of 82 ± 7%. The % TST with an SaO2 < 90% was 17 ± 29%. There was a significant inverse correlation between the AHI and TST (r=-0.78, p |
| doi_str_mv | 10.1093/sleep/zsy061.898 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2036663188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/sleep/zsy061.898</oup_id><sourcerecordid>2036663188</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1478-163e96f2b53c43c7824a5b76aaab77be6fb0449f1a1a0b4de5fdb6b139eb1ad73</originalsourceid><addsrcrecordid>eNqFkUtLxDAQx4MouD7uHgMepZps2rTxtnR9gdCV1XNJ2ikbaZOapMr6afyodq0XT56GYf4Phh9CZ5RcUiLYlW8B-qtPvyWcXmYi20MzmiQkEuN1H80I5TTKKEkO0ZH3r2TcY8Fm6ItkQuAlBHCdNtIEj22D17sw_DTIVoct1gavZNCwO37osMH5xlmjK1woH9xQBf0OeDW0nTXSbfFSe5AesDQ1zq2pbKfDGPxHPRUsegPyGocN4LxYLaNivcDFO7hW9ni9NbWzHZygg0a2Hk5_5zF6ub15zu-jx-LuIV88RhWN0yyinIHgzVwlrIpZlWbzWCYq5VJKlaYKeKNIHIuGSiqJimtImlpxRZkARWWdsmN0PuX2zr4N4EP5agdnxspyThjnnNEsG1VkUlXOeu-gKXunu_HrkpJyx6H84VBOHMqRw2i5mCx26P9XfwNTg462</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036663188</pqid></control><display><type>article</type><title>0899 Determinants of Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease and Concomitant Obstructive Sleep Apnea: the COPD-OSA Overlap Syndrome</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Krachman, S ; Jaffe, F ; Soler, X ; Chatila, W ; D’alonzo, G E ; Weaver, S ; Bakhsh, K ; Dhesi, S ; Shariff, T ; Criner, G ; Vega-Sanchez, M</creator><creatorcontrib>Krachman, S ; Jaffe, F ; Soler, X ; Chatila, W ; D’alonzo, G E ; Weaver, S ; Bakhsh, K ; Dhesi, S ; Shariff, T ; Criner, G ; Vega-Sanchez, M</creatorcontrib><description>Abstract
Introduction
In chronic obstructive pulmonary disease (COPD) patients without associated obstructive sleep apnea (OSA) quantitative measurements of sleep quality appear to be related to the severity of obstructive airways disease and nocturnal oxygenation. However, the determinants of sleep quality in patients with COPD-OSA overlap syndrome are unknown. We hypothesize that both parameters of airflow obstruction and severity of OSA contribute to the sleep quality in COPD-OSA overlap syndrome.
Methods
Participants were derived from the COPDGene project. The study included patients who underwent a full night polysomnogram (PSG) and where diagnosed with OSA (AHI≥ 5 events/hr). To confirm the presence of COPD, and prior to the PSG, patients had spirometry performed, and obtained a chest computed tomography (CT) for measurements of percent emphysema and gas trapping.
Results
Twenty-one patients [10 (48%) males, 57 ± 8 years/old, FEV1 1.2 ± 0.5 L, FEV1 %Predicted 45 ± 19%, FVC 2.3 ± 0.7 L, FVC %Predicted 68 ± 20%, FEV1/FVC 50 ± 11%, BMI 34 ± 9 kg/m2)] were diagnosed with OSA (apnea-hypopnea index [AHI] 16 ± 12 events/hour). The total sleep time (TST) was 286 ± 86 minutes with a sleep efficiency (SE) of 67 ± 23%.The Arousal index (AI) was 26 ± 27 arousals/hr. The mean SaO2 was 93 ± 3% with the lowest SaO2 of 82 ± 7%. The % TST with an SaO2 < 90% was 17 ± 29%. There was a significant inverse correlation between the AHI and TST (r=-0.78, p<0.001), and AHI and SE (r=-0.71, p<0.001) as well as the AHI and AI (r=-0.84, p<0.001). There was also a significant inverse correlation between the BMI and SE (r=-0.49, p=0.03). In addition, there was significant inverse correlation between % TST with an SaO2 < 90% and TST (r=-0.46, p=0.04).There was no correlation between TST, SE, or AI and FEV1 %Pred, FVC %Pred, CT-Derived % Emphysema, or CT-Derived % Gas Trapping.
Conclusion
In patients with COPD-OSA overlap syndrome,sleep quality, as measured by TST, SE, and AI appears to be mostly influenced by the severity of the patient’s OSA rather than the severity of their obstructive airways disease.
Support (If Any)
R01-HL089856, R01-HL089897.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsy061.898</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Chronic obstructive pulmonary disease ; Quality ; Sleep apnea</subject><ispartof>Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A334-A334</ispartof><rights>Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 Sleep Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Krachman, S</creatorcontrib><creatorcontrib>Jaffe, F</creatorcontrib><creatorcontrib>Soler, X</creatorcontrib><creatorcontrib>Chatila, W</creatorcontrib><creatorcontrib>D’alonzo, G E</creatorcontrib><creatorcontrib>Weaver, S</creatorcontrib><creatorcontrib>Bakhsh, K</creatorcontrib><creatorcontrib>Dhesi, S</creatorcontrib><creatorcontrib>Shariff, T</creatorcontrib><creatorcontrib>Criner, G</creatorcontrib><creatorcontrib>Vega-Sanchez, M</creatorcontrib><title>0899 Determinants of Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease and Concomitant Obstructive Sleep Apnea: the COPD-OSA Overlap Syndrome</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction
In chronic obstructive pulmonary disease (COPD) patients without associated obstructive sleep apnea (OSA) quantitative measurements of sleep quality appear to be related to the severity of obstructive airways disease and nocturnal oxygenation. However, the determinants of sleep quality in patients with COPD-OSA overlap syndrome are unknown. We hypothesize that both parameters of airflow obstruction and severity of OSA contribute to the sleep quality in COPD-OSA overlap syndrome.
Methods
Participants were derived from the COPDGene project. The study included patients who underwent a full night polysomnogram (PSG) and where diagnosed with OSA (AHI≥ 5 events/hr). To confirm the presence of COPD, and prior to the PSG, patients had spirometry performed, and obtained a chest computed tomography (CT) for measurements of percent emphysema and gas trapping.
Results
Twenty-one patients [10 (48%) males, 57 ± 8 years/old, FEV1 1.2 ± 0.5 L, FEV1 %Predicted 45 ± 19%, FVC 2.3 ± 0.7 L, FVC %Predicted 68 ± 20%, FEV1/FVC 50 ± 11%, BMI 34 ± 9 kg/m2)] were diagnosed with OSA (apnea-hypopnea index [AHI] 16 ± 12 events/hour). The total sleep time (TST) was 286 ± 86 minutes with a sleep efficiency (SE) of 67 ± 23%.The Arousal index (AI) was 26 ± 27 arousals/hr. The mean SaO2 was 93 ± 3% with the lowest SaO2 of 82 ± 7%. The % TST with an SaO2 < 90% was 17 ± 29%. There was a significant inverse correlation between the AHI and TST (r=-0.78, p<0.001), and AHI and SE (r=-0.71, p<0.001) as well as the AHI and AI (r=-0.84, p<0.001). There was also a significant inverse correlation between the BMI and SE (r=-0.49, p=0.03). In addition, there was significant inverse correlation between % TST with an SaO2 < 90% and TST (r=-0.46, p=0.04).There was no correlation between TST, SE, or AI and FEV1 %Pred, FVC %Pred, CT-Derived % Emphysema, or CT-Derived % Gas Trapping.
Conclusion
In patients with COPD-OSA overlap syndrome,sleep quality, as measured by TST, SE, and AI appears to be mostly influenced by the severity of the patient’s OSA rather than the severity of their obstructive airways disease.
Support (If Any)
R01-HL089856, R01-HL089897.</description><subject>Chronic obstructive pulmonary disease</subject><subject>Quality</subject><subject>Sleep apnea</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtLxDAQx4MouD7uHgMepZps2rTxtnR9gdCV1XNJ2ikbaZOapMr6afyodq0XT56GYf4Phh9CZ5RcUiLYlW8B-qtPvyWcXmYi20MzmiQkEuN1H80I5TTKKEkO0ZH3r2TcY8Fm6ItkQuAlBHCdNtIEj22D17sw_DTIVoct1gavZNCwO37osMH5xlmjK1woH9xQBf0OeDW0nTXSbfFSe5AesDQ1zq2pbKfDGPxHPRUsegPyGocN4LxYLaNivcDFO7hW9ni9NbWzHZygg0a2Hk5_5zF6ub15zu-jx-LuIV88RhWN0yyinIHgzVwlrIpZlWbzWCYq5VJKlaYKeKNIHIuGSiqJimtImlpxRZkARWWdsmN0PuX2zr4N4EP5agdnxspyThjnnNEsG1VkUlXOeu-gKXunu_HrkpJyx6H84VBOHMqRw2i5mCx26P9XfwNTg462</recordid><startdate>20180427</startdate><enddate>20180427</enddate><creator>Krachman, S</creator><creator>Jaffe, F</creator><creator>Soler, X</creator><creator>Chatila, W</creator><creator>D’alonzo, G E</creator><creator>Weaver, S</creator><creator>Bakhsh, K</creator><creator>Dhesi, S</creator><creator>Shariff, T</creator><creator>Criner, G</creator><creator>Vega-Sanchez, M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20180427</creationdate><title>0899 Determinants of Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease and Concomitant Obstructive Sleep Apnea: the COPD-OSA Overlap Syndrome</title><author>Krachman, S ; Jaffe, F ; Soler, X ; Chatila, W ; D’alonzo, G E ; Weaver, S ; Bakhsh, K ; Dhesi, S ; Shariff, T ; Criner, G ; Vega-Sanchez, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1478-163e96f2b53c43c7824a5b76aaab77be6fb0449f1a1a0b4de5fdb6b139eb1ad73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chronic obstructive pulmonary disease</topic><topic>Quality</topic><topic>Sleep apnea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krachman, S</creatorcontrib><creatorcontrib>Jaffe, F</creatorcontrib><creatorcontrib>Soler, X</creatorcontrib><creatorcontrib>Chatila, W</creatorcontrib><creatorcontrib>D’alonzo, G E</creatorcontrib><creatorcontrib>Weaver, S</creatorcontrib><creatorcontrib>Bakhsh, K</creatorcontrib><creatorcontrib>Dhesi, S</creatorcontrib><creatorcontrib>Shariff, T</creatorcontrib><creatorcontrib>Criner, G</creatorcontrib><creatorcontrib>Vega-Sanchez, M</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krachman, S</au><au>Jaffe, F</au><au>Soler, X</au><au>Chatila, W</au><au>D’alonzo, G E</au><au>Weaver, S</au><au>Bakhsh, K</au><au>Dhesi, S</au><au>Shariff, T</au><au>Criner, G</au><au>Vega-Sanchez, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0899 Determinants of Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease and Concomitant Obstructive Sleep Apnea: the COPD-OSA Overlap Syndrome</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2018-04-27</date><risdate>2018</risdate><volume>41</volume><issue>suppl_1</issue><spage>A334</spage><epage>A334</epage><pages>A334-A334</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction
In chronic obstructive pulmonary disease (COPD) patients without associated obstructive sleep apnea (OSA) quantitative measurements of sleep quality appear to be related to the severity of obstructive airways disease and nocturnal oxygenation. However, the determinants of sleep quality in patients with COPD-OSA overlap syndrome are unknown. We hypothesize that both parameters of airflow obstruction and severity of OSA contribute to the sleep quality in COPD-OSA overlap syndrome.
Methods
Participants were derived from the COPDGene project. The study included patients who underwent a full night polysomnogram (PSG) and where diagnosed with OSA (AHI≥ 5 events/hr). To confirm the presence of COPD, and prior to the PSG, patients had spirometry performed, and obtained a chest computed tomography (CT) for measurements of percent emphysema and gas trapping.
Results
Twenty-one patients [10 (48%) males, 57 ± 8 years/old, FEV1 1.2 ± 0.5 L, FEV1 %Predicted 45 ± 19%, FVC 2.3 ± 0.7 L, FVC %Predicted 68 ± 20%, FEV1/FVC 50 ± 11%, BMI 34 ± 9 kg/m2)] were diagnosed with OSA (apnea-hypopnea index [AHI] 16 ± 12 events/hour). The total sleep time (TST) was 286 ± 86 minutes with a sleep efficiency (SE) of 67 ± 23%.The Arousal index (AI) was 26 ± 27 arousals/hr. The mean SaO2 was 93 ± 3% with the lowest SaO2 of 82 ± 7%. The % TST with an SaO2 < 90% was 17 ± 29%. There was a significant inverse correlation between the AHI and TST (r=-0.78, p<0.001), and AHI and SE (r=-0.71, p<0.001) as well as the AHI and AI (r=-0.84, p<0.001). There was also a significant inverse correlation between the BMI and SE (r=-0.49, p=0.03). In addition, there was significant inverse correlation between % TST with an SaO2 < 90% and TST (r=-0.46, p=0.04).There was no correlation between TST, SE, or AI and FEV1 %Pred, FVC %Pred, CT-Derived % Emphysema, or CT-Derived % Gas Trapping.
Conclusion
In patients with COPD-OSA overlap syndrome,sleep quality, as measured by TST, SE, and AI appears to be mostly influenced by the severity of the patient’s OSA rather than the severity of their obstructive airways disease.
Support (If Any)
R01-HL089856, R01-HL089897.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsy061.898</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Chronic obstructive pulmonary disease Quality Sleep apnea |
| title | 0899 Determinants of Sleep Quality in Patients with Chronic Obstructive Pulmonary Disease and Concomitant Obstructive Sleep Apnea: the COPD-OSA Overlap Syndrome |
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