1022 Changes in The Sleep Quality And Caregiver Burden by Timed Blue Light in Alzheimer`s Disease
Abstract Introduction Sleep-wake disturbances are prevalent in patients with Alzheimer`s disease(AD), burdening distress for their caregivers. Therapeutic exposure to light has been shown to alter sleep-wake rhythms. However, previous studies on the light therapy(LT) for sleep-wake disturbances in A...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A379-A380 |
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| creator | Lee, J H Kim, S J Lee, S H Suh, I B Jang, J Jhoo, J H |
| description | Abstract
Introduction
Sleep-wake disturbances are prevalent in patients with Alzheimer`s disease(AD), burdening distress for their caregivers. Therapeutic exposure to light has been shown to alter sleep-wake rhythms. However, previous studies on the light therapy(LT) for sleep-wake disturbances in AD failed to yield consistent findings due to methodological issues. We aimed to examine the effect of timed blue-enriched light on subjective and objective sleep in AD patients and to evaluate changes in their caregiver burden.
Methods
We recruited patients with mild to moderate AD who had the Pittsburgh Sleep Quality Index(PSQI) score of 5 or greater and/or complained insomnia symptoms more than 3 times a week. The patients were randomly assigned to the treatment group(TG) or control group(CG). The dim light melatonin onset(DLMO) was determined from seven hourly saliva samples obtained before sleep onset measured by actigraphy(Actiwatch 2;Respironics, USA) for 5 days. Home-based one-hour blue-enriched light intervention(Litebook®EDGE™;Litebook, Canada) for 2 weeks was applied between 9 to 10 h after DLMO. The CG was to wear blue-blocked glasses during timed LT. The neuropsychiatric inventory(NPI) was used for assessing the neuropsychiatric symptoms of patients(NPI-S) and caregiver distress (NPI-D). Six patients(77.3 ± 3.3years) of TG and four patients(76.0 ± 10.7years) of CG were included. Changes in the values before and after timed LT were analyzed for each group.
Results
The PSQI scores of TG after timed LT were significantly decreased, compared to those before timed LT(p |
| doi_str_mv | 10.1093/sleep/zsy061.1021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2036657483</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/sleep/zsy061.1021</oup_id><sourcerecordid>2036657483</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1981-6fcdec9665c604f074d8d6e2b259c5de79e3df8aea7488ccabab71b52e55bfb73</originalsourceid><addsrcrecordid>eNqNkM1OwzAQhC0EEqXwANwscSXUTmInObbhV6qEEOVs_LNpUqVJsBuk9OlxCA_AabWzM7PSh9A1JXeUZNHC1QDd4ugGwqlXQnqCZpQxEmT-fIpmhHIapJSwc3Th3I74Pc6iGZLeG-K8lM0WHK4avCkBv49l-K2XdXUY8LIxOJcWttU3WLzqrYEGqwFvqj0YvKp7wOtqWx7G9LI-luB1--nwfeVAOrhEZ4WsHVz9zTn6eHzY5M_B-vXpJV-uA02zlAa80AZ0xjnTnMQFSWKTGg6hClmmmYEkg8gUqQSZxGmqtVRSJVSxEBhThUqiObqZejvbfvXgDmLX9rbxL0VIIt_rc5F30cmlbeuchUJ0ttpLOwhKxEhS_JIUE0kxkvSZ2ynT9t0_7D-Prncq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036657483</pqid></control><display><type>article</type><title>1022 Changes in The Sleep Quality And Caregiver Burden by Timed Blue Light in Alzheimer`s Disease</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Lee, J H ; Kim, S J ; Lee, S H ; Suh, I B ; Jang, J ; Jhoo, J H</creator><creatorcontrib>Lee, J H ; Kim, S J ; Lee, S H ; Suh, I B ; Jang, J ; Jhoo, J H</creatorcontrib><description>Abstract
Introduction
Sleep-wake disturbances are prevalent in patients with Alzheimer`s disease(AD), burdening distress for their caregivers. Therapeutic exposure to light has been shown to alter sleep-wake rhythms. However, previous studies on the light therapy(LT) for sleep-wake disturbances in AD failed to yield consistent findings due to methodological issues. We aimed to examine the effect of timed blue-enriched light on subjective and objective sleep in AD patients and to evaluate changes in their caregiver burden.
Methods
We recruited patients with mild to moderate AD who had the Pittsburgh Sleep Quality Index(PSQI) score of 5 or greater and/or complained insomnia symptoms more than 3 times a week. The patients were randomly assigned to the treatment group(TG) or control group(CG). The dim light melatonin onset(DLMO) was determined from seven hourly saliva samples obtained before sleep onset measured by actigraphy(Actiwatch 2;Respironics, USA) for 5 days. Home-based one-hour blue-enriched light intervention(Litebook®EDGE™;Litebook, Canada) for 2 weeks was applied between 9 to 10 h after DLMO. The CG was to wear blue-blocked glasses during timed LT. The neuropsychiatric inventory(NPI) was used for assessing the neuropsychiatric symptoms of patients(NPI-S) and caregiver distress (NPI-D). Six patients(77.3 ± 3.3years) of TG and four patients(76.0 ± 10.7years) of CG were included. Changes in the values before and after timed LT were analyzed for each group.
Results
The PSQI scores of TG after timed LT were significantly decreased, compared to those before timed LT(p<0.05) while there were no significant changes between sleep parameters before and after timed LT in both groups. The scores of NPI-S and NPI-D in TG were reduced after timed LT(11.0 ± 4.5 to8.5 ± 4.9;13.3 ± 9.1 to9.0 ± 8.1), but these were not significant.
Conclusion
After timed LT, AD patients did not show a significant improvement in objective sleep, but did in subjective sleep quality. Our finding also indicates timed LT might have a beneficial effect on the behavior disturbance of AD patients and their caregiver distress.
Support (If Any)
This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT &Future Planning(2017R1A2B4003493).</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsy061.1021</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Alzheimer's disease ; Caregivers ; Light ; Sleep</subject><ispartof>Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A379-A380</ispartof><rights>Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 Sleep Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1981-6fcdec9665c604f074d8d6e2b259c5de79e3df8aea7488ccabab71b52e55bfb73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Lee, J H</creatorcontrib><creatorcontrib>Kim, S J</creatorcontrib><creatorcontrib>Lee, S H</creatorcontrib><creatorcontrib>Suh, I B</creatorcontrib><creatorcontrib>Jang, J</creatorcontrib><creatorcontrib>Jhoo, J H</creatorcontrib><title>1022 Changes in The Sleep Quality And Caregiver Burden by Timed Blue Light in Alzheimer`s Disease</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction
Sleep-wake disturbances are prevalent in patients with Alzheimer`s disease(AD), burdening distress for their caregivers. Therapeutic exposure to light has been shown to alter sleep-wake rhythms. However, previous studies on the light therapy(LT) for sleep-wake disturbances in AD failed to yield consistent findings due to methodological issues. We aimed to examine the effect of timed blue-enriched light on subjective and objective sleep in AD patients and to evaluate changes in their caregiver burden.
Methods
We recruited patients with mild to moderate AD who had the Pittsburgh Sleep Quality Index(PSQI) score of 5 or greater and/or complained insomnia symptoms more than 3 times a week. The patients were randomly assigned to the treatment group(TG) or control group(CG). The dim light melatonin onset(DLMO) was determined from seven hourly saliva samples obtained before sleep onset measured by actigraphy(Actiwatch 2;Respironics, USA) for 5 days. Home-based one-hour blue-enriched light intervention(Litebook®EDGE™;Litebook, Canada) for 2 weeks was applied between 9 to 10 h after DLMO. The CG was to wear blue-blocked glasses during timed LT. The neuropsychiatric inventory(NPI) was used for assessing the neuropsychiatric symptoms of patients(NPI-S) and caregiver distress (NPI-D). Six patients(77.3 ± 3.3years) of TG and four patients(76.0 ± 10.7years) of CG were included. Changes in the values before and after timed LT were analyzed for each group.
Results
The PSQI scores of TG after timed LT were significantly decreased, compared to those before timed LT(p<0.05) while there were no significant changes between sleep parameters before and after timed LT in both groups. The scores of NPI-S and NPI-D in TG were reduced after timed LT(11.0 ± 4.5 to8.5 ± 4.9;13.3 ± 9.1 to9.0 ± 8.1), but these were not significant.
Conclusion
After timed LT, AD patients did not show a significant improvement in objective sleep, but did in subjective sleep quality. Our finding also indicates timed LT might have a beneficial effect on the behavior disturbance of AD patients and their caregiver distress.
Support (If Any)
This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT &Future Planning(2017R1A2B4003493).</description><subject>Alzheimer's disease</subject><subject>Caregivers</subject><subject>Light</subject><subject>Sleep</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkM1OwzAQhC0EEqXwANwscSXUTmInObbhV6qEEOVs_LNpUqVJsBuk9OlxCA_AabWzM7PSh9A1JXeUZNHC1QDd4ugGwqlXQnqCZpQxEmT-fIpmhHIapJSwc3Th3I74Pc6iGZLeG-K8lM0WHK4avCkBv49l-K2XdXUY8LIxOJcWttU3WLzqrYEGqwFvqj0YvKp7wOtqWx7G9LI-luB1--nwfeVAOrhEZ4WsHVz9zTn6eHzY5M_B-vXpJV-uA02zlAa80AZ0xjnTnMQFSWKTGg6hClmmmYEkg8gUqQSZxGmqtVRSJVSxEBhThUqiObqZejvbfvXgDmLX9rbxL0VIIt_rc5F30cmlbeuchUJ0ttpLOwhKxEhS_JIUE0kxkvSZ2ynT9t0_7D-Prncq</recordid><startdate>20180427</startdate><enddate>20180427</enddate><creator>Lee, J H</creator><creator>Kim, S J</creator><creator>Lee, S H</creator><creator>Suh, I B</creator><creator>Jang, J</creator><creator>Jhoo, J H</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20180427</creationdate><title>1022 Changes in The Sleep Quality And Caregiver Burden by Timed Blue Light in Alzheimer`s Disease</title><author>Lee, J H ; Kim, S J ; Lee, S H ; Suh, I B ; Jang, J ; Jhoo, J H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1981-6fcdec9665c604f074d8d6e2b259c5de79e3df8aea7488ccabab71b52e55bfb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alzheimer's disease</topic><topic>Caregivers</topic><topic>Light</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, J H</creatorcontrib><creatorcontrib>Kim, S J</creatorcontrib><creatorcontrib>Lee, S H</creatorcontrib><creatorcontrib>Suh, I B</creatorcontrib><creatorcontrib>Jang, J</creatorcontrib><creatorcontrib>Jhoo, J H</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, J H</au><au>Kim, S J</au><au>Lee, S H</au><au>Suh, I B</au><au>Jang, J</au><au>Jhoo, J H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1022 Changes in The Sleep Quality And Caregiver Burden by Timed Blue Light in Alzheimer`s Disease</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2018-04-27</date><risdate>2018</risdate><volume>41</volume><issue>suppl_1</issue><spage>A379</spage><epage>A380</epage><pages>A379-A380</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction
Sleep-wake disturbances are prevalent in patients with Alzheimer`s disease(AD), burdening distress for their caregivers. Therapeutic exposure to light has been shown to alter sleep-wake rhythms. However, previous studies on the light therapy(LT) for sleep-wake disturbances in AD failed to yield consistent findings due to methodological issues. We aimed to examine the effect of timed blue-enriched light on subjective and objective sleep in AD patients and to evaluate changes in their caregiver burden.
Methods
We recruited patients with mild to moderate AD who had the Pittsburgh Sleep Quality Index(PSQI) score of 5 or greater and/or complained insomnia symptoms more than 3 times a week. The patients were randomly assigned to the treatment group(TG) or control group(CG). The dim light melatonin onset(DLMO) was determined from seven hourly saliva samples obtained before sleep onset measured by actigraphy(Actiwatch 2;Respironics, USA) for 5 days. Home-based one-hour blue-enriched light intervention(Litebook®EDGE™;Litebook, Canada) for 2 weeks was applied between 9 to 10 h after DLMO. The CG was to wear blue-blocked glasses during timed LT. The neuropsychiatric inventory(NPI) was used for assessing the neuropsychiatric symptoms of patients(NPI-S) and caregiver distress (NPI-D). Six patients(77.3 ± 3.3years) of TG and four patients(76.0 ± 10.7years) of CG were included. Changes in the values before and after timed LT were analyzed for each group.
Results
The PSQI scores of TG after timed LT were significantly decreased, compared to those before timed LT(p<0.05) while there were no significant changes between sleep parameters before and after timed LT in both groups. The scores of NPI-S and NPI-D in TG were reduced after timed LT(11.0 ± 4.5 to8.5 ± 4.9;13.3 ± 9.1 to9.0 ± 8.1), but these were not significant.
Conclusion
After timed LT, AD patients did not show a significant improvement in objective sleep, but did in subjective sleep quality. Our finding also indicates timed LT might have a beneficial effect on the behavior disturbance of AD patients and their caregiver distress.
Support (If Any)
This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT &Future Planning(2017R1A2B4003493).</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsy061.1021</doi><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Alzheimer's disease Caregivers Light Sleep |
| title | 1022 Changes in The Sleep Quality And Caregiver Burden by Timed Blue Light in Alzheimer`s Disease |
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