0300 Comparison of Sleep Disturbance and Quantitative Volumetric MRI Measures in Veterans With and Without History of Mild Traumatic Brain Injury (mTBI)
Abstract Introduction Mild traumatic brain injury (mTBI) has received considerable clinical and research attention in recent years. Scientific reviews have determined that upwards of 70% of individuals who experience mTBI may later report having trouble sleeping with over 50% of patients reporting i...
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| creator | Orff, H J Sorg, S F Holiday, K A Clark, A L Delano-Wood, L Schiehser, D M |
| description | Abstract
Introduction
Mild traumatic brain injury (mTBI) has received considerable clinical and research attention in recent years. Scientific reviews have determined that upwards of 70% of individuals who experience mTBI may later report having trouble sleeping with over 50% of patients reporting insomnia. Observed estimates of sleep disturbance in Veterans with history of mTBI are even higher. What is less known is whether Veterans with mTBI exhibit worse sleep than Veterans without mTBI and whether these sleep impairments are associated with neurophysiological changes.
Methods
61 Veterans with history of mTBI (age:31.1+/-5.3; 85%male) and 33 Veterans with no history of mTBI (age:30.4+/-6.1; 85%male) were studied. The Pittsburgh Sleep Quality Inventory (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and a structural MRI were administered. Sleep measures were compared using ANCOVA controlling for PTSD symptomatology (PTSD Checklist-Military). FMRIB’s Software (FSL) was utilized to obtain whole brain and volume estimates from 7 bilateral regions which were compared between groups using independent t-tests (controlling for intercranial volume). Bivariate correlations were performed only for those sleep measures and volumetric data that were determined to differ significantly between groups.
Results
ANCOVA determined that Veterans with mTBI reported significantly greater sleep impairments on the ISI (p |
| doi_str_mv | 10.1093/sleep/zsy061.299 |
| format | Article |
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Introduction
Mild traumatic brain injury (mTBI) has received considerable clinical and research attention in recent years. Scientific reviews have determined that upwards of 70% of individuals who experience mTBI may later report having trouble sleeping with over 50% of patients reporting insomnia. Observed estimates of sleep disturbance in Veterans with history of mTBI are even higher. What is less known is whether Veterans with mTBI exhibit worse sleep than Veterans without mTBI and whether these sleep impairments are associated with neurophysiological changes.
Methods
61 Veterans with history of mTBI (age:31.1+/-5.3; 85%male) and 33 Veterans with no history of mTBI (age:30.4+/-6.1; 85%male) were studied. The Pittsburgh Sleep Quality Inventory (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and a structural MRI were administered. Sleep measures were compared using ANCOVA controlling for PTSD symptomatology (PTSD Checklist-Military). FMRIB’s Software (FSL) was utilized to obtain whole brain and volume estimates from 7 bilateral regions which were compared between groups using independent t-tests (controlling for intercranial volume). Bivariate correlations were performed only for those sleep measures and volumetric data that were determined to differ significantly between groups.
Results
ANCOVA determined that Veterans with mTBI reported significantly greater sleep impairments on the ISI (p<.027) and ESS (p<.016), with a trend on the PSQI (p=.059). Independent samples t-tests of the volumetric data found significantly lower brain volume in Veterans with mTBI in the left accumbens (p=.001), right accumbens (p=.02), and a trend for left hippocampus (p=.06). Bivariate correlations found a significant negative association between insomnia severity (ISI) and left hippocampal volume (r=-.307, p=.016) for Veterans with mTBI.
Conclusion
This investigation determined two principle findings: 1) Veterans with history of mTBI report significantly poorer sleep than Veterans without a history of mTBI accounting for PTSD symptomatology, and 2) greater insomnia symptomatology in Veterans with mTBI may be associated with lower hippocampal volume. Future studies should investigate this link further and ascertain the potential impact of hippocampal changes on cognitive outcomes.
Support (If Any)
VA-RR&D-CDA-1IK2-RX001512-01A2(HJO) and VA-CSR&D-CDA-2-065-10S(DMS).</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsy061.299</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Insomnia ; Magnetic resonance imaging ; Sleep ; Traumatic brain injury</subject><ispartof>Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A115-A115</ispartof><rights>Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 Sleep Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Orff, H J</creatorcontrib><creatorcontrib>Sorg, S F</creatorcontrib><creatorcontrib>Holiday, K A</creatorcontrib><creatorcontrib>Clark, A L</creatorcontrib><creatorcontrib>Delano-Wood, L</creatorcontrib><creatorcontrib>Schiehser, D M</creatorcontrib><title>0300 Comparison of Sleep Disturbance and Quantitative Volumetric MRI Measures in Veterans With and Without History of Mild Traumatic Brain Injury (mTBI)</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction
Mild traumatic brain injury (mTBI) has received considerable clinical and research attention in recent years. Scientific reviews have determined that upwards of 70% of individuals who experience mTBI may later report having trouble sleeping with over 50% of patients reporting insomnia. Observed estimates of sleep disturbance in Veterans with history of mTBI are even higher. What is less known is whether Veterans with mTBI exhibit worse sleep than Veterans without mTBI and whether these sleep impairments are associated with neurophysiological changes.
Methods
61 Veterans with history of mTBI (age:31.1+/-5.3; 85%male) and 33 Veterans with no history of mTBI (age:30.4+/-6.1; 85%male) were studied. The Pittsburgh Sleep Quality Inventory (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and a structural MRI were administered. Sleep measures were compared using ANCOVA controlling for PTSD symptomatology (PTSD Checklist-Military). FMRIB’s Software (FSL) was utilized to obtain whole brain and volume estimates from 7 bilateral regions which were compared between groups using independent t-tests (controlling for intercranial volume). Bivariate correlations were performed only for those sleep measures and volumetric data that were determined to differ significantly between groups.
Results
ANCOVA determined that Veterans with mTBI reported significantly greater sleep impairments on the ISI (p<.027) and ESS (p<.016), with a trend on the PSQI (p=.059). Independent samples t-tests of the volumetric data found significantly lower brain volume in Veterans with mTBI in the left accumbens (p=.001), right accumbens (p=.02), and a trend for left hippocampus (p=.06). Bivariate correlations found a significant negative association between insomnia severity (ISI) and left hippocampal volume (r=-.307, p=.016) for Veterans with mTBI.
Conclusion
This investigation determined two principle findings: 1) Veterans with history of mTBI report significantly poorer sleep than Veterans without a history of mTBI accounting for PTSD symptomatology, and 2) greater insomnia symptomatology in Veterans with mTBI may be associated with lower hippocampal volume. Future studies should investigate this link further and ascertain the potential impact of hippocampal changes on cognitive outcomes.
Support (If Any)
VA-RR&D-CDA-1IK2-RX001512-01A2(HJO) and VA-CSR&D-CDA-2-065-10S(DMS).</description><subject>Insomnia</subject><subject>Magnetic resonance imaging</subject><subject>Sleep</subject><subject>Traumatic brain injury</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkEtPG0EQhEdRIsVxcs9xJC5BaE3PvucIJoAlLETimOOqvdujjOXdWeaB5PyS_FzGmDun7lbXVyUVY98FzATI7NztiMbzf24PpZilUn5gE1EUkMj4_cgmIEqR1AKKz-yLc1uIdy6zCfsPGQCfm35Eq50ZuFH898GKX2nng93g0BLHoeMPAQevPXr9THxtdqEnb3XLl78WfEnogiXH9cDX5Mni4Pij9n9fycNigue30dHY_SFiqXcdX1kMffRr-aXFSC6GbYjvH_3qcnH6lX1SuHP07W1O2Z_rn6v5bXJ3f7OYX9wlrcgrmVTdJledkiVIwIK6LkWVt1h3CpXIUdBGiSoX2UaIlFrZpQRtWuaFwErWhHU2ZSdH39Gap0DON1sT7BAjmxSysiwqqLOogqOqtcY5S6oZre7R7hsBzaH_5rX_5th_E_uPyNkRMWF8X_0CzPqLOg</recordid><startdate>20180427</startdate><enddate>20180427</enddate><creator>Orff, H J</creator><creator>Sorg, S F</creator><creator>Holiday, K A</creator><creator>Clark, A L</creator><creator>Delano-Wood, L</creator><creator>Schiehser, D M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20180427</creationdate><title>0300 Comparison of Sleep Disturbance and Quantitative Volumetric MRI Measures in Veterans With and Without History of Mild Traumatic Brain Injury (mTBI)</title><author>Orff, H J ; Sorg, S F ; Holiday, K A ; Clark, A L ; Delano-Wood, L ; Schiehser, D M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1479-7db4fdf96090a5edd2af4ca8dfaf14a1ebf17413b112ec9d2e0c26451a798ea83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Insomnia</topic><topic>Magnetic resonance imaging</topic><topic>Sleep</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orff, H J</creatorcontrib><creatorcontrib>Sorg, S F</creatorcontrib><creatorcontrib>Holiday, K A</creatorcontrib><creatorcontrib>Clark, A L</creatorcontrib><creatorcontrib>Delano-Wood, L</creatorcontrib><creatorcontrib>Schiehser, D M</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orff, H J</au><au>Sorg, S F</au><au>Holiday, K A</au><au>Clark, A L</au><au>Delano-Wood, L</au><au>Schiehser, D M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0300 Comparison of Sleep Disturbance and Quantitative Volumetric MRI Measures in Veterans With and Without History of Mild Traumatic Brain Injury (mTBI)</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2018-04-27</date><risdate>2018</risdate><volume>41</volume><issue>suppl_1</issue><spage>A115</spage><epage>A115</epage><pages>A115-A115</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction
Mild traumatic brain injury (mTBI) has received considerable clinical and research attention in recent years. Scientific reviews have determined that upwards of 70% of individuals who experience mTBI may later report having trouble sleeping with over 50% of patients reporting insomnia. Observed estimates of sleep disturbance in Veterans with history of mTBI are even higher. What is less known is whether Veterans with mTBI exhibit worse sleep than Veterans without mTBI and whether these sleep impairments are associated with neurophysiological changes.
Methods
61 Veterans with history of mTBI (age:31.1+/-5.3; 85%male) and 33 Veterans with no history of mTBI (age:30.4+/-6.1; 85%male) were studied. The Pittsburgh Sleep Quality Inventory (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and a structural MRI were administered. Sleep measures were compared using ANCOVA controlling for PTSD symptomatology (PTSD Checklist-Military). FMRIB’s Software (FSL) was utilized to obtain whole brain and volume estimates from 7 bilateral regions which were compared between groups using independent t-tests (controlling for intercranial volume). Bivariate correlations were performed only for those sleep measures and volumetric data that were determined to differ significantly between groups.
Results
ANCOVA determined that Veterans with mTBI reported significantly greater sleep impairments on the ISI (p<.027) and ESS (p<.016), with a trend on the PSQI (p=.059). Independent samples t-tests of the volumetric data found significantly lower brain volume in Veterans with mTBI in the left accumbens (p=.001), right accumbens (p=.02), and a trend for left hippocampus (p=.06). Bivariate correlations found a significant negative association between insomnia severity (ISI) and left hippocampal volume (r=-.307, p=.016) for Veterans with mTBI.
Conclusion
This investigation determined two principle findings: 1) Veterans with history of mTBI report significantly poorer sleep than Veterans without a history of mTBI accounting for PTSD symptomatology, and 2) greater insomnia symptomatology in Veterans with mTBI may be associated with lower hippocampal volume. Future studies should investigate this link further and ascertain the potential impact of hippocampal changes on cognitive outcomes.
Support (If Any)
VA-RR&D-CDA-1IK2-RX001512-01A2(HJO) and VA-CSR&D-CDA-2-065-10S(DMS).</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsy061.299</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Insomnia Magnetic resonance imaging Sleep Traumatic brain injury |
| title | 0300 Comparison of Sleep Disturbance and Quantitative Volumetric MRI Measures in Veterans With and Without History of Mild Traumatic Brain Injury (mTBI) |
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