Are cucurbiturils better drug carriers for bent metallocenes? Insights from theory

Bent metallocenes (BM) have anti-tumor properties but they face a serious drug efficacy problem due to poor aqueous solubility and rapid hydrolysis under physiological conditions. These two problems can be fixed by encapsulating them in host molecules such as cyclodextrin (CD), cucurbituril (CB) etc...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2018-05, Vol.23 (3), p.413-423
Hauptverfasser:	Senthilnathan, Dhurairajan, Solomon, Rajadurai Vijay, Kiruthika, Shanmugam, Venuvanalingam, Ponnambalam, Sundararajan, Mahesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Biochemistry Biomedical and Life Sciences Cadmium Cations Chlorine Drug Carriers - administration & dosage Drug Carriers - chemistry Drug delivery Electrostatic properties Host systems Hydrogen bonding Hydrolysis Inorganic chemistry Life Sciences Macrocyclic Compounds - administration & dosage Macrocyclic Compounds - chemistry Metallocenes - administration & dosage Metallocenes - chemistry Microbiology Original Paper Protons β-Cyclodextrin
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