Optimization of 18F‐syntheses using 19F‐reagents at tracer‐level concentrations and liquid chromatography/tandem mass spectrometry analysis: Improved synthesis of [18F]MDL100907

Traditional radiosynthetic optimization faces the challenges of high radiation exposure, cost, and inability to perform serial reactions due to tracer decay. To accelerate tracer development, we have developed a strategy to simulate radioactive 18F‐syntheses by using tracer‐level (nanomolar) non‐rad...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2018-05, Vol.61 (5), p.427-437
Hauptverfasser:	Zhang, Xiang, Dunlow, Ryan, Blackman, Burchelle N., Swenson, Rolf E.
Format:	Artikel
Sprache:	eng
Schlagworte:	18F 19F Chemists fallypride Liquid chromatography Mass spectrometry Mass spectroscopy MDL100907 Optimization Radiation effects Radioactivity Radiochemical analysis Reagents Synthesis tracer‐level
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