Surface Imprinting on Spherical Macroporous Silica for Protein Recognition

A novel surface imprinting method on macroporous SiO2 microspheres with highly ordered three-dimensional interconnected structure has been developed for bovine hemoglobin (BHb) protein recognition. The selective experiment showed that the synthesized macroporous microspheres exhibited good specific...

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Veröffentlicht in:Chemistry letters 2018-05, Vol.47 (5), p.686-689
Hauptverfasser: Xu, DanDan, Li, SiQi, Pan, Ting, He, JianFeng, Wu, QuanZhou
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container_title Chemistry letters
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creator Xu, DanDan
Li, SiQi
Pan, Ting
He, JianFeng
Wu, QuanZhou
description A novel surface imprinting method on macroporous SiO2 microspheres with highly ordered three-dimensional interconnected structure has been developed for bovine hemoglobin (BHb) protein recognition. The selective experiment showed that the synthesized macroporous microspheres exhibited good specific recognition for template molecules. Compared with the traditional bulk imprinted polymers, the surface imprinting microspheres showed higher binding kinetic behavior, and its binding rate constant was nearly about 7 times as large as that of the bulk imprinted polymers.
doi_str_mv 10.1246/cl.180050
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source Oxford University Press Journals All Titles (1996-Current)
subjects Binding
Chemical synthesis
Hemoglobin
Imprinted polymers
Microspheres
Molecular chains
Recognition
Silicon dioxide
title Surface Imprinting on Spherical Macroporous Silica for Protein Recognition
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