MOLECULAR MECHANISMS OF DRUG SENSITIVITY OF RICE BLAST FUNGI MAGNAPORTHE GRISEA TO TRIAZOLES IN CHINA
In the last few years resistance to azole fungicides has appeared in infected crops and has become more serious. Our aim was to analyse the reasons underlying the progressive decrease in the effectiveness of azole fungicides in controlling Magnaporthe grisea, the causal agent of rice blast. Forty-ni...
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description | In the last few years resistance to azole fungicides has appeared in infected crops and has become more serious. Our aim was to analyse the reasons underlying the progressive decrease in the effectiveness of azole fungicides in controlling Magnaporthe grisea, the causal agent of rice blast. Forty-nine isolates of M. grisea were isolated from Hubei, Hunan, Jiangsu and Heilongjiang provinces in China. Their sensitivity to five sterol demethylation inhibitors, such as diniconazole, tebuconazole, triadimenol, triadimefon and propiconazole was measured. Three insensitive isolates (HM2, CY3 and CY6) and three hypersensitive isolates (CY8, YA10 and 101301) were characterised to elucidate the sensitivity mechanism to triazoles. Through a comparison of M13 fingerprinting, CYP51 sequences and expression, the results indicated that the genetic background of M. grisea isolates and CYP51 expression are conserved. However, the substitution of S312L in SRS4 of M. grisea CYP51F2 may contribute to the sensitivity difference of M. grisea to triazoles. |
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Our aim was to analyse the reasons underlying the progressive decrease in the effectiveness of azole fungicides in controlling Magnaporthe grisea, the causal agent of rice blast. Forty-nine isolates of M. grisea were isolated from Hubei, Hunan, Jiangsu and Heilongjiang provinces in China. Their sensitivity to five sterol demethylation inhibitors, such as diniconazole, tebuconazole, triadimenol, triadimefon and propiconazole was measured. Three insensitive isolates (HM2, CY3 and CY6) and three hypersensitive isolates (CY8, YA10 and 101301) were characterised to elucidate the sensitivity mechanism to triazoles. Through a comparison of M13 fingerprinting, CYP51 sequences and expression, the results indicated that the genetic background of M. grisea isolates and CYP51 expression are conserved. 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Our aim was to analyse the reasons underlying the progressive decrease in the effectiveness of azole fungicides in controlling Magnaporthe grisea, the causal agent of rice blast. Forty-nine isolates of M. grisea were isolated from Hubei, Hunan, Jiangsu and Heilongjiang provinces in China. Their sensitivity to five sterol demethylation inhibitors, such as diniconazole, tebuconazole, triadimenol, triadimefon and propiconazole was measured. Three insensitive isolates (HM2, CY3 and CY6) and three hypersensitive isolates (CY8, YA10 and 101301) were characterised to elucidate the sensitivity mechanism to triazoles. Through a comparison of M13 fingerprinting, CYP51 sequences and expression, the results indicated that the genetic background of M. grisea isolates and CYP51 expression are conserved. 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Our aim was to analyse the reasons underlying the progressive decrease in the effectiveness of azole fungicides in controlling Magnaporthe grisea, the causal agent of rice blast. Forty-nine isolates of M. grisea were isolated from Hubei, Hunan, Jiangsu and Heilongjiang provinces in China. Their sensitivity to five sterol demethylation inhibitors, such as diniconazole, tebuconazole, triadimenol, triadimefon and propiconazole was measured. Three insensitive isolates (HM2, CY3 and CY6) and three hypersensitive isolates (CY8, YA10 and 101301) were characterised to elucidate the sensitivity mechanism to triazoles. Through a comparison of M13 fingerprinting, CYP51 sequences and expression, the results indicated that the genetic background of M. grisea isolates and CYP51 expression are conserved. However, the substitution of S312L in SRS4 of M. grisea CYP51F2 may contribute to the sensitivity difference of M. grisea to triazoles.</abstract><cop>Freising</cop><pub>Parlar Scientific Publications</pub></addata></record> |
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subjects | Demethylation DNA fingerprinting Fingerprinting Fungi Fungicides Gene sequencing Molecular modelling Pathogens Pesticides Propiconazole Rice blast Sensitivity Tebuconazole Triadimefon Triadimenol Triazoles |
title | MOLECULAR MECHANISMS OF DRUG SENSITIVITY OF RICE BLAST FUNGI MAGNAPORTHE GRISEA TO TRIAZOLES IN CHINA |
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