Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats
Background: Hedyotis corymbosa Linn. (family: Rubiaceae) has been used in the Indian indigenous system of medicine, Ayurveda, for treatment of various health aliments. Objectives: The present study was undertaken to evaluate the antidepressant activity of methanolic extract of whole plant of H. cory...
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| Veröffentlicht in: | Pharmacognosy research 2018-04, Vol.10 (2), p.213-217 |
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| description | Background: Hedyotis corymbosa Linn. (family: Rubiaceae) has been used in the Indian indigenous system of medicine, Ayurveda, for treatment of various health aliments. Objectives: The present study was undertaken to evaluate the antidepressant activity of methanolic extract of whole plant of H. corymbosa (MHC) in olfactory bulbectomy rats. Materials and Methods: MHC was prepared and standardized to gallic acid by high-performance thin-layer chromatograph method. Effects of 14 days oral treatment of fluoxetine (30 mg/kg) and three doses of MHC (50, 100, and 200 mg/kg) were evaluated on olfactory bulbectomy (OBX)-induced alterations in behavioral and biochemical parameters in rats. Results: MHC treatment reversed the OBX-induced behavioral abnormalities such as increased exploratory activity in open-field paradigm and decreased feeding latency time in novelty-suppressed feeding test. Serum cortisol levels were restored near to normal by the MHC treatment. Further, treatment of MHC prevented the OBX-induced decline of brain levels of serotonin and nor-adrenaline in dose-dependent manner. Conclusion: MHC prevents behavioral and neurochemical changes in OBX-induced depression in rats. These results demonstrate the antidepressant effect of H. corymbosa and support its folklore claim.
Abbreviations Used: ANOVA: one-way analysis of variance; CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals; ELIZA: Enzyme-linked immunosorbent assay; HPTLC: High-performance thin-layer chromatography; MHC: Methanolic extract of Hedyotis corymbosa; NA: Noradrenaline; OBX: Olfactory bulbectomy; SEM: Standard error of mean; TLC: Thin layer chromatography; 5-HT: 5-hydroxytryptamine; 5-HIAA: 5-hydroxyindoleacetic acid. |
| doi_str_mv | 10.4103/pr.pr_118_17 |
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Abbreviations Used: ANOVA: one-way analysis of variance; CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals; ELIZA: Enzyme-linked immunosorbent assay; HPTLC: High-performance thin-layer chromatography; MHC: Methanolic extract of Hedyotis corymbosa; NA: Noradrenaline; OBX: Olfactory bulbectomy; SEM: Standard error of mean; TLC: Thin layer chromatography; 5-HT: 5-hydroxytryptamine; 5-HIAA: 5-hydroxyindoleacetic acid.</description><identifier>ISSN: 0974-8490</identifier><identifier>ISSN: 0976-4836</identifier><identifier>EISSN: 0974-8490</identifier><identifier>DOI: 10.4103/pr.pr_118_17</identifier><language>eng</language><publisher>Bangalore: Wolters Kluwer India Pvt. Ltd</publisher><subject>Animals ; Antidepressants ; Ayurvedic medicine ; Brain research ; Carbohydrates ; Dopamine ; Drug dosages ; Flavonoids ; Fluoxetine ; Herbal medicine ; Life sciences ; Pharmacology ; Pharmacy ; Phytochemicals ; Surgery</subject><ispartof>Pharmacognosy research, 2018-04, Vol.10 (2), p.213-217</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt. Ltd. Apr/Jun 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385r-5d317a33a75ce3fd7ade7fbee863bb6a6be8e5fe0eb7152f096714a89fbb247d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Pawar, Anil</creatorcontrib><creatorcontrib>Gaikwad, Gayatri</creatorcontrib><creatorcontrib>Kuchekar, Bhanudas</creatorcontrib><title>Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats</title><title>Pharmacognosy research</title><description>Background: Hedyotis corymbosa Linn. (family: Rubiaceae) has been used in the Indian indigenous system of medicine, Ayurveda, for treatment of various health aliments. Objectives: The present study was undertaken to evaluate the antidepressant activity of methanolic extract of whole plant of H. corymbosa (MHC) in olfactory bulbectomy rats. Materials and Methods: MHC was prepared and standardized to gallic acid by high-performance thin-layer chromatograph method. Effects of 14 days oral treatment of fluoxetine (30 mg/kg) and three doses of MHC (50, 100, and 200 mg/kg) were evaluated on olfactory bulbectomy (OBX)-induced alterations in behavioral and biochemical parameters in rats. Results: MHC treatment reversed the OBX-induced behavioral abnormalities such as increased exploratory activity in open-field paradigm and decreased feeding latency time in novelty-suppressed feeding test. Serum cortisol levels were restored near to normal by the MHC treatment. Further, treatment of MHC prevented the OBX-induced decline of brain levels of serotonin and nor-adrenaline in dose-dependent manner. Conclusion: MHC prevents behavioral and neurochemical changes in OBX-induced depression in rats. These results demonstrate the antidepressant effect of H. corymbosa and support its folklore claim.
Abbreviations Used: ANOVA: one-way analysis of variance; CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals; ELIZA: Enzyme-linked immunosorbent assay; HPTLC: High-performance thin-layer chromatography; MHC: Methanolic extract of Hedyotis corymbosa; NA: Noradrenaline; OBX: Olfactory bulbectomy; SEM: Standard error of mean; TLC: Thin layer chromatography; 5-HT: 5-hydroxytryptamine; 5-HIAA: 5-hydroxyindoleacetic acid.</description><subject>Animals</subject><subject>Antidepressants</subject><subject>Ayurvedic medicine</subject><subject>Brain research</subject><subject>Carbohydrates</subject><subject>Dopamine</subject><subject>Drug dosages</subject><subject>Flavonoids</subject><subject>Fluoxetine</subject><subject>Herbal medicine</subject><subject>Life sciences</subject><subject>Pharmacology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Surgery</subject><issn>0974-8490</issn><issn>0976-4836</issn><issn>0974-8490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkV1LwzAUhoMoOObu_AEFb-1MmjZpb4Qx1AkDvdDrkDQn0q1tatIy--_NmJ-w5CLn5DzvOSQvQpcEz1OC6U3n5p0ThOSC8BM0wQVP4zwt8Omf-BzNvN_gsGiRFCmZoOdF21caOgfey7aPwBgo-8iaaAV6tH3lo9K6sVHWywg-eidDtWojW5sQhUqkhloFiW3GyMneX6AzI2sPs69zil7v716Wq3j99PC4XKzjkuaZizNNCZeUSp6VQI3mUgM3CiBnVCkmmYIcMgMYFCdZYnDBOEllXhilkpRrOkVXh76ds-8D-F5s7ODaMFIkmGJCMCvYL_UmaxBVa-z-BU3lS7HIKMOMha8I1PwIFbaGpiptC6YK9_8E1wdB6az3DozoXNVINwqCxd6NkIsfNwJ-e8B3tu7B-W097MCJBvS2tbujGpEQKr69oZ-SIpP_</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Pawar, Anil</creator><creator>Gaikwad, Gayatri</creator><creator>Kuchekar, Bhanudas</creator><general>Wolters Kluwer India Pvt. 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Ltd</general><general>Phcog.net</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180401</creationdate><title>Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats</title><author>Pawar, Anil ; Gaikwad, Gayatri ; Kuchekar, Bhanudas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385r-5d317a33a75ce3fd7ade7fbee863bb6a6be8e5fe0eb7152f096714a89fbb247d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antidepressants</topic><topic>Ayurvedic medicine</topic><topic>Brain research</topic><topic>Carbohydrates</topic><topic>Dopamine</topic><topic>Drug dosages</topic><topic>Flavonoids</topic><topic>Fluoxetine</topic><topic>Herbal medicine</topic><topic>Life sciences</topic><topic>Pharmacology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawar, Anil</creatorcontrib><creatorcontrib>Gaikwad, Gayatri</creatorcontrib><creatorcontrib>Kuchekar, Bhanudas</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pharmacognosy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawar, Anil</au><au>Gaikwad, Gayatri</au><au>Kuchekar, Bhanudas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats</atitle><jtitle>Pharmacognosy research</jtitle><date>2018-04-01</date><risdate>2018</risdate><volume>10</volume><issue>2</issue><spage>213</spage><epage>217</epage><pages>213-217</pages><issn>0974-8490</issn><issn>0976-4836</issn><eissn>0974-8490</eissn><abstract>Background: Hedyotis corymbosa Linn. (family: Rubiaceae) has been used in the Indian indigenous system of medicine, Ayurveda, for treatment of various health aliments. Objectives: The present study was undertaken to evaluate the antidepressant activity of methanolic extract of whole plant of H. corymbosa (MHC) in olfactory bulbectomy rats. Materials and Methods: MHC was prepared and standardized to gallic acid by high-performance thin-layer chromatograph method. Effects of 14 days oral treatment of fluoxetine (30 mg/kg) and three doses of MHC (50, 100, and 200 mg/kg) were evaluated on olfactory bulbectomy (OBX)-induced alterations in behavioral and biochemical parameters in rats. Results: MHC treatment reversed the OBX-induced behavioral abnormalities such as increased exploratory activity in open-field paradigm and decreased feeding latency time in novelty-suppressed feeding test. Serum cortisol levels were restored near to normal by the MHC treatment. Further, treatment of MHC prevented the OBX-induced decline of brain levels of serotonin and nor-adrenaline in dose-dependent manner. Conclusion: MHC prevents behavioral and neurochemical changes in OBX-induced depression in rats. These results demonstrate the antidepressant effect of H. corymbosa and support its folklore claim.
Abbreviations Used: ANOVA: one-way analysis of variance; CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals; ELIZA: Enzyme-linked immunosorbent assay; HPTLC: High-performance thin-layer chromatography; MHC: Methanolic extract of Hedyotis corymbosa; NA: Noradrenaline; OBX: Olfactory bulbectomy; SEM: Standard error of mean; TLC: Thin layer chromatography; 5-HT: 5-hydroxytryptamine; 5-HIAA: 5-hydroxyindoleacetic acid.</abstract><cop>Bangalore</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><doi>10.4103/pr.pr_118_17</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antidepressants Ayurvedic medicine Brain research Carbohydrates Dopamine Drug dosages Flavonoids Fluoxetine Herbal medicine Life sciences Pharmacology Pharmacy Phytochemicals Surgery |
| title | Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats |
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