Nontargeted SWATH acquisition mode for metabolites identification of osthole in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

Osthole (OST), 7-methoxy-8-isopentenoxycoumarin, is the characteristic constituent found in Cnidium monnieri (L.) Cuss. and possesses excellent pharmacological activities, including anticancer, anti-apoptosis and neuroprotection. In this study, a rapid and reliable method based on ultra-high-perform...

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Veröffentlicht in:	RSC advances 2018-01, Vol.8 (27), p.14925-14935
Hauptverfasser:	Liao, Man, Diao, Xinpeng, Cheng, Xiaoye, Sun, Yupeng, Zhang, Lantong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Biological properties Chemistry Chromatography Conjugation Cysteine Data acquisition Data processing Dehydrogenation Filtration High performance liquid chromatography Hunting Ions Liver Mass spectrometry Metabolism Metabolites Oxidation Pharmacology Phosphorylation Quadrupoles Scientific imaging Spectroscopy Urine
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