Development of 2-arylbenzo[]quinolone analogs as selective CYP1B1 inhibitors

The CYP1B1 enzyme is regarded as a potential target for cancer prevention and therapy. Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo[ h ]quinolone derivatives were designed, synthesized and evaluated as selective CYP1B1 inhibitors. Compared with ANF, although few of the title...

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Veröffentlicht in:	RSC advances 2018-01, Vol.8 (27), p.159-152
Hauptverfasser:	Dong, Jinyun, Wang, Zengtao, Meng, Qingqing, Zhang, Qijing, Huang, Guang, Cui, Jiahua, Li, Shaoshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Inhibitors Selectivity
Online-Zugang:	Volltext
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