Canonical Wnt Signaling in CD11c + APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon

Aberrant Wnt/β-catenin signaling occurs in several inflammatory diseases, including inflammatory bowel disease and inflammatory bowel disease-associated colon carcinogenesis. However, its role in shaping mucosal immune responses to commensals in the gut remains unknown. In this study, we investigate...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-05, Vol.200 (9), p.3259-3268
Hauptverfasser:	Swafford, Daniel, Shanmugam, Arulkumaran, Ranganathan, Punithavathi, Hussein, Mohamed S, Koni, Pandelakis A, Prasad, Puttur D, Thangaraju, Muthusamy, Manicassamy, Santhakumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-presenting cells Antigen-Presenting Cells - immunology Carcinogenesis CD11c antigen Cell activation Clonal deletion Colitis, Ulcerative - immunology Colitis, Ulcerative - microbiology Colon Colon - immunology Colon - microbiology Commensals Gastrointestinal Microbiome - immunology Homeostasis Homeostasis - immunology Immune response Immunity, Mucosal - immunology Inflammation Inflammation - immunology Inflammatory bowel disease Inflammatory bowel diseases Inflammatory diseases Interleukin 10 Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestine LRP5 protein Lymphocytes T Mice Mice, Inbred C57BL Mice, Transgenic Microbiota Microflora Mucosal immunity Phenotypes Proteins Receptor density Retinoic acid Rodents Signal transduction Ulcerative colitis Wnt protein Wnt Signaling Pathway - immunology β-Catenin
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