Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway

Oxidative stress is considered a crucial mediator in the pathogenesis of various liver diseases. The flavone diosmetin has been reported to exhibit antioxidant activities; however, the hepatoprotective effects of diosmetin against oxidative stress, and the underlying molecular mechanisms, remain unk...

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Veröffentlicht in:	Molecular medicine reports 2018-05, Vol.17 (5), p.7331-7338
Hauptverfasser:	Wang, Chunjing, Liao, Yaping, Wang, Shengnan, Wang, Dan, Wu, Nana, Xu, Qingao, Jiang, Wanwan, Qiu, Menran, Liu, Changqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antioxidants Antioxidants (Nutrients) Apoptosis Biotechnology Cell activation Cholecystokinin Complications and side effects Development and progression Drug therapy Enzymes Flavonoids Flow cytometry Gene expression Genetic aspects Heme Heme oxygenase (decyclizing) Homeostasis Hydrogen peroxide Intracellular L-Lactate dehydrogenase Lactic acid Liver diseases Membrane potential Membrane proteins Mitochondria Molecular modelling NAD Oxidative stress Oxidoreductase Oxygenase Physiological aspects Polymerase chain reaction Protein expression Proteins Reactive oxygen species Signal transduction Studies Transcription factors Vitamin E Western blotting
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