Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice

Tetrahydropalmatine exerts numerous pharmacological activities, including analgesic and narcotic effects; anti-arrhythmic, blood pressure lowering and cardioprotective effects; protective effects against cerebral ischemia-reperfusion injury; inhibition of platelet aggregation; prevention of ulcerati...

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Veröffentlicht in:	Molecular medicine reports 2018-05, Vol.17 (5), p.6873-6880
Hauptverfasser:	Zhang, Yonglai, Sha, Rui, Wang, Kaiguo, Li, Hao, Yan, Bo, Zhou, Naibao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholinesterase Analgesics Anesthesia Animals Anti-Inflammatory Agents - therapeutic use Antioxidants - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Berberine Alkaloids - therapeutic use Biotechnology Blood pressure Brain research Care and treatment Caspase Caspase-3 Caspase-9 Cognitive ability Complications and side effects Corydalis Cytochrome c Drug addiction Enzyme-linked immunosorbent assay Escape learning Gastric juice Glial cell line-derived neurotrophic factor Glial fibrillary acidic protein Inflammation Ischemia Ketamine Ketamine - adverse effects Kinases Laboratory animals Latency Learning disorders Male Maze Learning - drug effects Memory Memory - drug effects Memory disorders Memory Disorders - chemically induced Memory Disorders - pathology Memory Disorders - prevention & control Mice, Inbred C57BL Nervous system Neuronal-glial interactions Oxidative Stress - drug effects Pediatrics Protein expression Proteins Reperfusion Risk factors Rodents Secretion Studies Surgery Systems development Tumor necrosis factor-TNF Western blotting Withdrawal
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