Cerebral dopaminergic and glutamatergic transmission relate to different subjective responses of acute alcohol intake: an in vivo multimodal imaging study

Converging preclinical evidence links extrastriatal dopamine release and glutamatergic transmission via the metabotropic glutamate receptor 5 (mGluR5) to the rewarding properties of alcohol. To date, human evidence is lacking on how and where in the brain these processes occur. Mesocorticolimbic dop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Addiction biology 2018-05, Vol.23 (3), p.931-944
Hauptverfasser:	Leurquin‐Sterk, Gil, Ceccarini, Jenny, Crunelle, Cleo Lina, Weerasekera, Akila, Laat, Bart, Himmelreich, Uwe, Bormans, Guy, Van Laere, Koen
Format:	Artikel
Sprache:	eng
Schlagworte:	[1H]MRS Adult Alcohol Alcoholic beverages Benzamides Brain - diagnostic imaging Brain - drug effects Brain - metabolism Caudate nucleus Caudate Nucleus - diagnostic imaging Caudate Nucleus - drug effects Caudate Nucleus - metabolism Central Nervous System Depressants - pharmacology Cortex (cingulate) Cortex (parietal) Cortex (temporal) Dopamine Dopamine - metabolism Dopamine receptors Ethanol - pharmacology Female glutamate Glutamatergic transmission Glutamic Acid - drug effects Glutamic Acid - metabolism Glutamic acid receptors (metabotropic) Glutamine Glutamine - drug effects Glutamine - metabolism Humans Infusions, Intravenous Intravenous administration Magnetic resonance spectroscopy Male Medical imaging Middle Aged Motivation Neuroimaging Neurotransmitters Nitriles Parietal Lobe PET Positron emission tomography Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proton Magnetic Resonance Spectroscopy Pyridines Pyrrolidines Radiopharmaceuticals Receptor, Metabotropic Glutamate 5 - drug effects Receptor, Metabotropic Glutamate 5 - metabolism Reinforcement Spectrum analysis subjective effects Synaptic Transmission - drug effects Temporal lobe Temporal Lobe - diagnostic imaging Temporal Lobe - drug effects Temporal Lobe - metabolism Thalamus Thalamus - diagnostic imaging Thalamus - drug effects Thalamus - metabolism Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!