Blocking antibodies induced by allergen‐specific immunotherapy ameliorate allergic airway disease in a human/mouse chimeric model

Background Allergen‐specific immunotherapy (AIT) induces specific blocking antibodies (Ab), which are claimed to prevent IgE‐mediated reactions to allergens. Additionally, AIT modulates cellular responses to allergens, for example, by desensitizing effector cells, inducing regulatory T and B lymphoc...

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Veröffentlicht in:	Allergy (Copenhagen) 2018-04, Vol.73 (4), p.851-861
Hauptverfasser:	Vizzardelli, C., Gindl, M., Roos, S., Möbs, C., Nagl, B., Zimmann, F., Sexl, V., Kenner, L., Neunkirchner, A., Zlabinger, G. J., Pickl, W. F., Pfützner, W., Bohle, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens allergen‐specific immunotherapy Allergies allergy Animals Antibodies, Blocking - immunology Asthma - immunology Blocking antibodies Cell suspensions Chimera chimeric human/mouse model Desensitization Desensitization, Immunologic Diabetes Diabetes mellitus Disease Models, Animal Effector cells Female Flow cytometry Humans Hypersensitivity - immunology Immune deviation Immunodeficiency Immunoglobulin E Immunological tolerance Immunotherapy Inflammation Lymphocytes Lymphocytes B Lymphocytes T Male Mice Mice, Inbred NOD Mice, SCID nonobese diabetic severe combined immunodeficient γc−/− mouse Peripheral blood mononuclear cells Pollen Respiratory tract diseases
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