Richter transformation driven by Epstein–Barr virus reactivation during therapy‐related immunosuppression in chronic lymphocytic leukaemia

The increased risk of Richter transformation (RT) in patients with chronic lymphocytic leukaemia (CLL) due to Epstein–Barr virus (EBV) reactivation during immunosuppressive therapy with fludarabine other targeted agents remains controversial. Among 31 RT cases classified as diffuse large B‐cell lymp...

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Veröffentlicht in:	The Journal of pathology 2018-05, Vol.245 (1), p.61-73
Hauptverfasser:	García‐Barchino, Maria J, Sarasquete, Maria E, Panizo, Carlos, Morscio, Julie, Martinez, Antonio, Alcoceba, Miguel, Fresquet, Vicente, Gonzalez‐Farre, Blanca, Paiva, Bruno, Young, Ken H, Robles, Eloy F, Roa, Sergio, Celay, Jon, Larrayoz, Marta, Rossi, Davide, Gaidano, Gianluca, Montes‐Moreno, Santiago, Piris, Miguel A, Balanzategui, Ana, Jimenez, Cristina, Rodriguez, Idoia, Calasanz, Maria J, Larrayoz, Maria J, Segura, Victor, Garcia‐Muñoz, Ricardo, Rabasa, Maria P, Yi, Shuhua, Li, Jianyong, Zhang, Mingzhi, Xu‐Monette, Zijun Y, Puig‐Moron, Noemi, Orfao, Alberto, Böttcher, Sebastian, Hernandez‐Rivas, Jesus M, Miguel, Jesus San, Prosper, Felipe, Tousseyn, Thomas, Sagaert, Xavier, Gonzalez, Marcos, Martinez‐Climent, Jose A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Blood cells Chronic lymphocytic leukemia EBV Epstein-Barr virus Fludarabine Ganciclovir Genetic transformation Immunosuppression Immunosuppressive agents Immunosurveillance Immunotherapy Latency Leukemia Lymphocytes Lymphocytes B Lymphocytosis Lymphoma Phenotypes RAG2 protein Richter transformation therapy‐related immunosuppression Transformations Transplantation Tumors Viruses Xenografts
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