Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation

Excessive autophagy/mitophagy plays important roles during cerebral ischemia-reperfusion (I/R) injury. Peroxynitrite (ONOO − ), a representative reactive nitrogen species, mediates excessive mitophagy activation and exacerbates cerebral I/R injury. In the present study, we tested the hypothesis that...

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Veröffentlicht in:	Molecular neurobiology 2018-12, Vol.55 (12), p.9029-9042
Hauptverfasser:	Feng, Jinghan, Chen, Xingmiao, Lu, Shengwen, Li, Wenting, Yang, Dan, Su, Weiwei, Wang, Xijun, Shen, Jiangang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apoptosis Autophagy Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain injury Brain Ischemia - drug therapy Brain Ischemia - pathology Cell Biology Cell death Cell Line, Tumor Cell size Cell Survival - drug effects Cerebrum Flavanones - pharmacokinetics Flavanones - pharmacology Flavanones - therapeutic use Humans Ischemia Male Mitochondria Mitophagy Mitophagy - drug effects NAD(P)H oxidase NADPH Oxidases - metabolism Neurobiology Neurology Neurosciences Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase Nitrotyrosine Oxygen - pharmacology Parkin protein Peroxynitrite Peroxynitrous Acid Phagocytosis Rats, Sprague-Dawley Reactive nitrogen species Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - pathology Rodents Superoxide Translocation Tyrosine - analogs & derivatives Tyrosine - metabolism
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