Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders
Purpose Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from health...
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| Veröffentlicht in: | European journal of applied physiology 2018-07, Vol.118 (7), p.1301-1307 |
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| container_title | European journal of applied physiology |
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| creator | Jensen, Jacob K. Nygaard, Rie H. Svensson, Rene B. Hove, Hanne D. Magnusson, S. Peter Kjær, Michael Couppé, Christian |
| description | Purpose
Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (
n
= 7) compared to healthy controls (
n
= 14).
Methods
The mechanical properties of the patellar tendon were assessed using simultaneous force and ultrasonographic measurements during isometric ramp contractions. Ultrasonography was also used to measure tendon dimensions. The HCTD children were matched with 2 healthy controls with regard to age, body mass index (BMI), sex and physical activity level.
Results
The HCTD children had a greater degree of joint laxity (
P
|
| doi_str_mv | 10.1007/s00421-018-3862-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2022043989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2022043989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-adb72df6f535143945e4a93ebbc57b0c6d5325b923cf1832bf148d6dddedc6eb3</originalsourceid><addsrcrecordid>eNp1kElPwzAQhS0EoqXwA7ggS5wDXrIeAbFJlbjA2fIyJq5Sp9gOiH9PqpRy4jQjzXtvZj6Ezim5ooRU15GQnNGM0Drjdcmy6gDNac6brOSsOtz3tJmhkxhXhJCa0foYzVhTMp4TMkf21vVr0K30TssOb0K_gZAcRNxbnFrAG5mg62TACbzpPXYe69Z1JoDHXy61uIXgklQdYN17Dzq5T8DJxTgANi72wUCIp-jIyi7C2a4u0NvD_evdU7Z8eXy-u1lmOmckZdKoihlb2oIX2-PzAnLZcFBKF5UiujQFZ4VqGNeW1pwpS_PalMYYMLoExRfocsodH_kYICax6ofgx5WCEcbImFk3o4pOKh36GANYsQluLcO3oERsyYqJrBjJii1ZUY2ei13yoNZg9o5flKOATYI4jvw7hL_V_6f-ANukhdA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2022043989</pqid></control><display><type>article</type><title>Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Jensen, Jacob K. ; Nygaard, Rie H. ; Svensson, Rene B. ; Hove, Hanne D. ; Magnusson, S. Peter ; Kjær, Michael ; Couppé, Christian</creator><creatorcontrib>Jensen, Jacob K. ; Nygaard, Rie H. ; Svensson, Rene B. ; Hove, Hanne D. ; Magnusson, S. Peter ; Kjær, Michael ; Couppé, Christian</creatorcontrib><description>Purpose
Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (
n
= 7) compared to healthy controls (
n
= 14).
Methods
The mechanical properties of the patellar tendon were assessed using simultaneous force and ultrasonographic measurements during isometric ramp contractions. Ultrasonography was also used to measure tendon dimensions. The HCTD children were matched with 2 healthy controls with regard to age, body mass index (BMI), sex and physical activity level.
Results
The HCTD children had a greater degree of joint laxity (
P
< 0.01). Although, the patellar tendon dimensions did not differ significantly between the two groups, the HCTD children showed a tendency toward a larger patellar tendon cross-sectional area (CSA) (35%,
P
= 0.19). Moreover, stiffness did not differ between the two groups, but secant modulus was 27% lower in children with a HCTD (
P
= 0.05) at common force and 34% lower at maximum force (
P
= 0.02).
Conclusions
The present study demonstrates for the first time that children with HCTDs have lower material properties (modulus) of their patellar tendon, which may be indicative of general impairment of connective tissue mechanics related to their increased joint laxity.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-018-3862-7</identifier><identifier>PMID: 29623400</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adolescents ; Biomechanical Phenomena ; Biomechanics ; Biomedical and Life Sciences ; Biomedicine ; Body mass index ; Child ; Children ; Ehlers-Danlos syndrome ; Ehlers-Danlos Syndrome - physiopathology ; Female ; Human Physiology ; Humans ; Isometric ; Joint Instability - physiopathology ; Knee ; Male ; Marfan syndrome ; Marfan Syndrome - physiopathology ; Mechanical properties ; Occupational Medicine/Industrial Medicine ; Original Article ; Patellar Ligament - diagnostic imaging ; Patellar Ligament - physiopathology ; Physical activity ; Sports Medicine ; Ultrasound</subject><ispartof>European journal of applied physiology, 2018-07, Vol.118 (7), p.1301-1307</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>European Journal of Applied Physiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-adb72df6f535143945e4a93ebbc57b0c6d5325b923cf1832bf148d6dddedc6eb3</citedby><cites>FETCH-LOGICAL-c420t-adb72df6f535143945e4a93ebbc57b0c6d5325b923cf1832bf148d6dddedc6eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-018-3862-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-018-3862-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29623400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Jacob K.</creatorcontrib><creatorcontrib>Nygaard, Rie H.</creatorcontrib><creatorcontrib>Svensson, Rene B.</creatorcontrib><creatorcontrib>Hove, Hanne D.</creatorcontrib><creatorcontrib>Magnusson, S. Peter</creatorcontrib><creatorcontrib>Kjær, Michael</creatorcontrib><creatorcontrib>Couppé, Christian</creatorcontrib><title>Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (
n
= 7) compared to healthy controls (
n
= 14).
Methods
The mechanical properties of the patellar tendon were assessed using simultaneous force and ultrasonographic measurements during isometric ramp contractions. Ultrasonography was also used to measure tendon dimensions. The HCTD children were matched with 2 healthy controls with regard to age, body mass index (BMI), sex and physical activity level.
Results
The HCTD children had a greater degree of joint laxity (
P
< 0.01). Although, the patellar tendon dimensions did not differ significantly between the two groups, the HCTD children showed a tendency toward a larger patellar tendon cross-sectional area (CSA) (35%,
P
= 0.19). Moreover, stiffness did not differ between the two groups, but secant modulus was 27% lower in children with a HCTD (
P
= 0.05) at common force and 34% lower at maximum force (
P
= 0.02).
Conclusions
The present study demonstrates for the first time that children with HCTDs have lower material properties (modulus) of their patellar tendon, which may be indicative of general impairment of connective tissue mechanics related to their increased joint laxity.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body mass index</subject><subject>Child</subject><subject>Children</subject><subject>Ehlers-Danlos syndrome</subject><subject>Ehlers-Danlos Syndrome - physiopathology</subject><subject>Female</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Isometric</subject><subject>Joint Instability - physiopathology</subject><subject>Knee</subject><subject>Male</subject><subject>Marfan syndrome</subject><subject>Marfan Syndrome - physiopathology</subject><subject>Mechanical properties</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Patellar Ligament - diagnostic imaging</subject><subject>Patellar Ligament - physiopathology</subject><subject>Physical activity</subject><subject>Sports Medicine</subject><subject>Ultrasound</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kElPwzAQhS0EoqXwA7ggS5wDXrIeAbFJlbjA2fIyJq5Sp9gOiH9PqpRy4jQjzXtvZj6Ezim5ooRU15GQnNGM0Drjdcmy6gDNac6brOSsOtz3tJmhkxhXhJCa0foYzVhTMp4TMkf21vVr0K30TssOb0K_gZAcRNxbnFrAG5mg62TACbzpPXYe69Z1JoDHXy61uIXgklQdYN17Dzq5T8DJxTgANi72wUCIp-jIyi7C2a4u0NvD_evdU7Z8eXy-u1lmOmckZdKoihlb2oIX2-PzAnLZcFBKF5UiujQFZ4VqGNeW1pwpS_PalMYYMLoExRfocsodH_kYICax6ofgx5WCEcbImFk3o4pOKh36GANYsQluLcO3oERsyYqJrBjJii1ZUY2ei13yoNZg9o5flKOATYI4jvw7hL_V_6f-ANukhdA</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Jensen, Jacob K.</creator><creator>Nygaard, Rie H.</creator><creator>Svensson, Rene B.</creator><creator>Hove, Hanne D.</creator><creator>Magnusson, S. Peter</creator><creator>Kjær, Michael</creator><creator>Couppé, Christian</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180701</creationdate><title>Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders</title><author>Jensen, Jacob K. ; Nygaard, Rie H. ; Svensson, Rene B. ; Hove, Hanne D. ; Magnusson, S. Peter ; Kjær, Michael ; Couppé, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-adb72df6f535143945e4a93ebbc57b0c6d5325b923cf1832bf148d6dddedc6eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body mass index</topic><topic>Child</topic><topic>Children</topic><topic>Ehlers-Danlos syndrome</topic><topic>Ehlers-Danlos Syndrome - physiopathology</topic><topic>Female</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Isometric</topic><topic>Joint Instability - physiopathology</topic><topic>Knee</topic><topic>Male</topic><topic>Marfan syndrome</topic><topic>Marfan Syndrome - physiopathology</topic><topic>Mechanical properties</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Patellar Ligament - diagnostic imaging</topic><topic>Patellar Ligament - physiopathology</topic><topic>Physical activity</topic><topic>Sports Medicine</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Jacob K.</creatorcontrib><creatorcontrib>Nygaard, Rie H.</creatorcontrib><creatorcontrib>Svensson, Rene B.</creatorcontrib><creatorcontrib>Hove, Hanne D.</creatorcontrib><creatorcontrib>Magnusson, S. Peter</creatorcontrib><creatorcontrib>Kjær, Michael</creatorcontrib><creatorcontrib>Couppé, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Jacob K.</au><au>Nygaard, Rie H.</au><au>Svensson, Rene B.</au><au>Hove, Hanne D.</au><au>Magnusson, S. Peter</au><au>Kjær, Michael</au><au>Couppé, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>118</volume><issue>7</issue><spage>1301</spage><epage>1307</epage><pages>1301-1307</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (
n
= 7) compared to healthy controls (
n
= 14).
Methods
The mechanical properties of the patellar tendon were assessed using simultaneous force and ultrasonographic measurements during isometric ramp contractions. Ultrasonography was also used to measure tendon dimensions. The HCTD children were matched with 2 healthy controls with regard to age, body mass index (BMI), sex and physical activity level.
Results
The HCTD children had a greater degree of joint laxity (
P
< 0.01). Although, the patellar tendon dimensions did not differ significantly between the two groups, the HCTD children showed a tendency toward a larger patellar tendon cross-sectional area (CSA) (35%,
P
= 0.19). Moreover, stiffness did not differ between the two groups, but secant modulus was 27% lower in children with a HCTD (
P
= 0.05) at common force and 34% lower at maximum force (
P
= 0.02).
Conclusions
The present study demonstrates for the first time that children with HCTDs have lower material properties (modulus) of their patellar tendon, which may be indicative of general impairment of connective tissue mechanics related to their increased joint laxity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29623400</pmid><doi>10.1007/s00421-018-3862-7</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2018-07, Vol.118 (7), p.1301-1307 |
| issn | 1439-6319 1439-6327 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adolescent Adolescents Biomechanical Phenomena Biomechanics Biomedical and Life Sciences Biomedicine Body mass index Child Children Ehlers-Danlos syndrome Ehlers-Danlos Syndrome - physiopathology Female Human Physiology Humans Isometric Joint Instability - physiopathology Knee Male Marfan syndrome Marfan Syndrome - physiopathology Mechanical properties Occupational Medicine/Industrial Medicine Original Article Patellar Ligament - diagnostic imaging Patellar Ligament - physiopathology Physical activity Sports Medicine Ultrasound |
| title | Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders |
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