Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis

BackgroundOpioids such as morphine are widely used for the management of pain associated with acute pancreatitis. Interestingly, opioids are also known to affect the immune system and modulate inflammatory pathways in non-pancreatic diseases. However, the impact of morphine on the progression of acu...

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Veröffentlicht in:	Gut 2018-04, Vol.67 (4), p.600
Hauptverfasser:	Barlass, Usman, Dutta, Raini, Cheema, Hassam, George, John, Sareen, Archana, Dixit, Ajay, Yuan, Zuobiao, Giri, Bhuwan, Meng, Jingjing, Banerjee, Santanu, Banerjee, Sulagna, Dudeja, Vikas, Dawra, Rajinder K, Roy, Sabita, Saluja, Ashok K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Analgesia Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Animal models Animals Arginine Bacteremia Cell activation Ceruletide Disease Disease Models, Animal Disease Progression Edema Embryos Ethanol Fatty Acids, Monounsaturated Gangrene Gastroenterology Immune system Immunofluorescence Inflammation Kinases Leukocytes (neutrophilic) Macrophages Mice Mice, Knockout Morbidity Morphine Morphine - administration & dosage Morphine - adverse effects Morphology Mortality Naltrexone Narcotics Neutrophils Opioid receptors (type mu) Pain Pain perception Palmitoleic acid Pancreas Pancreas - pathology Pancreatic diseases Pancreatitis Pancreatitis - chemically induced Pancreatitis - diagnosis Pancreatitis - drug therapy Permeability Rodents Severity of Illness Index Signal transduction Time Factors Transcription activation Transcription factors
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