MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer

Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor development. However, the regulatory mechanism and biological contributions of MIIP in pancreatic cancer (PC) have been not elucidated. In this study, we demonstrated a negative feedback of MIIP and hypo...

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Veröffentlicht in:	Oncogene 2018-03, Vol.37 (13), p.1743-1758
Hauptverfasser:	Niu, Yi, Jin, Yan, Deng, Shi-Chang, Deng, Shi-Jiang, Zhu, Shuai, Liu, Yang, Li, Xiang, He, Chi, Liu, Ming-Liang, Zeng, Zhu, Chen, Heng-Yu, Zhong, Jian-Xin, Ye, Zeng, Wang, Chun-You, Zhao, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/89 38/22 38/61 38/77 38/90 38/91 631/67/1504/1713 631/67/322 631/67/327 631/67/395 64/60 82/51 82/80 Acetylation Adult Aged Animal models Animals Apoptosis Carcinogenesis - genetics Carrier Proteins - genetics Cell adhesion & migration Cell Biology Cell proliferation Cell Proliferation - genetics Cells, Cultured Chromatin Down-Regulation - genetics Female Gene Expression Regulation, Neoplastic Histone deacetylase Human Genetics Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Immunoprecipitation Internal Medicine Intracellular Signaling Peptides and Proteins Male Medicine Medicine & Public Health Metastases Mice Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - physiology Middle Aged miRNA mRNA stability Neoplasm Invasiveness Oncology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pheochromocytoma cells Post-transcription Regulatory sequences Tumor Hypoxia - genetics Tumorigenesis Xenografts
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