STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

The pre-T cell receptor (pre-TCR) that minimally consists of the TCRβ chain and the disulfide-linked pre-T cell receptor alpha (pTα) chain in association with signal-transducing CD3 molecules rescues from programmed cell death cells with productive TCRβ rearrangements. The pre-TCR induces expansion...

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Veröffentlicht in:	Annual review of immunology 1997-01, Vol.15 (1), p.433-452
Hauptverfasser:	von Boehmer, Harald, Fehling, Hans Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD3 Complex - metabolism Cell Differentiation Chromosome Mapping Gene Expression Regulation, Developmental Humans Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Molecular Structure pre-TCRα pTα Receptors, Antigen, T-Cell, alpha-beta - chemistry Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism Signal Transduction T cell development T cell receptor T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology thymus
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