THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

One of the characteristic features of Hodgkin's disease (HD) is the presence of a small population of often bizarre-looking large mono- or multinucleated Hodgkin and Reed-Sternberg (HRS) cells within the affected tissue. Recent cytogenetic investigations, studies of Epstein-Barr virus (EBV) gen...

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Veröffentlicht in:	Annual review of immunology 1998-01, Vol.16 (1), p.471-493
Hauptverfasser:	Küppers, Ralf, Rajewsky, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals clonality Clone Cells Epstein-Barr virus Gene Rearrangement germinal center Herpesviridae Infections - genetics Herpesviridae Infections - pathology Herpesvirus 4, Human Hodgkin Disease - genetics Hodgkin Disease - pathology Humans Reed-Sternberg Cells - pathology single cell studies somatic hypermutation Tumor Virus Infections - genetics Tumor Virus Infections - pathology
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