Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection
Background: The opportunistic pathogen Klebsiella pneumoniae is one of the main causes of pediatric bacterial blood stream infections (BSI), which is complicated with sepsis and high mortality.Objectives: To identify atypical Klebsiella species affecting a sample of infected neonates with low antimi...
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| Veröffentlicht in: | Jundishapur journal of microbiology 2018-03, Vol.11 (3), p.1-6 |
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| creator | Cifuentes Castaneda, Damian David Ramirez Duran, Ninfa Espinoza Rivera, Iliana Marcela Caro Gonzalez, Luz Pablo Antonio Moreno Perez, Martin Mendieta Zeron, Hugo |
| description | Background: The opportunistic pathogen Klebsiella pneumoniae is one of the main causes of pediatric bacterial blood stream infections (BSI), which is complicated with sepsis and high mortality.Objectives: To identify atypical Klebsiella species affecting a sample of infected neonates with low antimicrobial response.Methods: Multidrug resistant blood cultures for Klebsiella from a Neonatal Service, were submitted to molecular identification by sequencing analysis of 16S ribosomal RNA.Results: The mean age of the newborns was 14.7 ± 5.6 days. A total of 6 out of 8 cases were sepsis, 1 case of pneumonia, and 1 a catheter-related infection. The molecular identification showed 3 cases of K. pneumoniae subsp. ozaenae, 2 of K. pneumoniae and K. variicola, and 1 case of K. oxytoca. The highest antimicrobial resistance was against cephalosporins and Trimethoprim/sulfamethoxazole.Conclusions: Klebsiella pneumoniae subsp. ozaenae was responsible for multidrug resistant strains of Klebsiella even in 37.5% of cases. In our clinical setting, the use of Amikacin and carbapenems are still useful to treat neonatal infections by Klebsiella even against K. variicola, which is the most resistant. |
| doi_str_mv | 10.5812/jjm.62393 |
| format | Article |
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A total of 6 out of 8 cases were sepsis, 1 case of pneumonia, and 1 a catheter-related infection. The molecular identification showed 3 cases of K. pneumoniae subsp. ozaenae, 2 of K. pneumoniae and K. variicola, and 1 case of K. oxytoca. The highest antimicrobial resistance was against cephalosporins and Trimethoprim/sulfamethoxazole.Conclusions: Klebsiella pneumoniae subsp. ozaenae was responsible for multidrug resistant strains of Klebsiella even in 37.5% of cases. In our clinical setting, the use of Amikacin and carbapenems are still useful to treat neonatal infections by Klebsiella even against K. variicola, which is the most resistant.</description><identifier>ISSN: 2008-3645</identifier><identifier>EISSN: 2008-4161</identifier><identifier>DOI: 10.5812/jjm.62393</identifier><language>eng</language><publisher>Ahvaz: Ahvaz Jundishapur University of Medical Sciences</publisher><subject>Amikacin ; Antimicrobial agents ; Antimicrobial resistance ; Blood ; Carbapenems ; Cephalosporins ; Deoxyribonucleic acid ; DNA ; Drug resistance ; Epidemiology ; Identification ; Infections ; Klebsiella ; Klebsiella pneumoniae ; Mortality ; Multidrug resistance ; Neonates ; Opportunist infection ; Pediatrics ; Pneumonia ; Polymerase chain reaction ; rRNA 16S ; Sepsis ; Sulfamethoxazole ; Trimethoprim</subject><ispartof>Jundishapur journal of microbiology, 2018-03, Vol.11 (3), p.1-6</ispartof><rights>Copyright Ahvaz Jundishapur University of Medical Sciences Mar 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-15d1f8488cb4d971109b331bc0cbcd9733ebf8444cad058353bb9a3cd212660b3</citedby><cites>FETCH-LOGICAL-c292t-15d1f8488cb4d971109b331bc0cbcd9733ebf8444cad058353bb9a3cd212660b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Cifuentes Castaneda, Damian David</creatorcontrib><creatorcontrib>Ramirez Duran, Ninfa</creatorcontrib><creatorcontrib>Espinoza Rivera, Iliana</creatorcontrib><creatorcontrib>Marcela Caro Gonzalez, Luz</creatorcontrib><creatorcontrib>Pablo Antonio Moreno Perez, Martin</creatorcontrib><creatorcontrib>Mendieta Zeron, Hugo</creatorcontrib><title>Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection</title><title>Jundishapur journal of microbiology</title><description>Background: The opportunistic pathogen Klebsiella pneumoniae is one of the main causes of pediatric bacterial blood stream infections (BSI), which is complicated with sepsis and high mortality.Objectives: To identify atypical Klebsiella species affecting a sample of infected neonates with low antimicrobial response.Methods: Multidrug resistant blood cultures for Klebsiella from a Neonatal Service, were submitted to molecular identification by sequencing analysis of 16S ribosomal RNA.Results: The mean age of the newborns was 14.7 ± 5.6 days. A total of 6 out of 8 cases were sepsis, 1 case of pneumonia, and 1 a catheter-related infection. The molecular identification showed 3 cases of K. pneumoniae subsp. ozaenae, 2 of K. pneumoniae and K. variicola, and 1 case of K. oxytoca. The highest antimicrobial resistance was against cephalosporins and Trimethoprim/sulfamethoxazole.Conclusions: Klebsiella pneumoniae subsp. ozaenae was responsible for multidrug resistant strains of Klebsiella even in 37.5% of cases. In our clinical setting, the use of Amikacin and carbapenems are still useful to treat neonatal infections by Klebsiella even against K. variicola, which is the most resistant.</description><subject>Amikacin</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Blood</subject><subject>Carbapenems</subject><subject>Cephalosporins</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Epidemiology</subject><subject>Identification</subject><subject>Infections</subject><subject>Klebsiella</subject><subject>Klebsiella pneumoniae</subject><subject>Mortality</subject><subject>Multidrug resistance</subject><subject>Neonates</subject><subject>Opportunist infection</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Polymerase chain reaction</subject><subject>rRNA 16S</subject><subject>Sepsis</subject><subject>Sulfamethoxazole</subject><subject>Trimethoprim</subject><issn>2008-3645</issn><issn>2008-4161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotkE1PwzAMhiMEEtPYgX8QiROHjnw1S49TBWxiggPjHCWpK1J1TUk6pP17WjZfbL1-ZEsPQveULHNF2VPTHJaS8YJfoRkjRGWCSnp9mbkU-S1apNSQqVZECTZD-_Vw6r0zLX5rwSYPbWvwZw_OQ8K-wwbvv32s8A5-ocWbkHo_jLBJuDTHBDjU-B1CZ6Zw29XgBh-6O3RTmzbB4tLn6OvleV9ust3H67Zc7zLHCjZkNK9orYRSzoqqWFFKCss5tY4468aAc7DjXghnKpIrnnNrC8NdxSiTklg-Rw_nu30MP0dIg27CMXbjS80IlVwSyehIPZ4pF0NKEWrdR38w8aQp0ZM3PXrT_974HxBTXsI</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Cifuentes Castaneda, Damian David</creator><creator>Ramirez Duran, Ninfa</creator><creator>Espinoza Rivera, Iliana</creator><creator>Marcela Caro Gonzalez, Luz</creator><creator>Pablo Antonio Moreno Perez, Martin</creator><creator>Mendieta Zeron, Hugo</creator><general>Ahvaz Jundishapur University of Medical Sciences</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180301</creationdate><title>Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection</title><author>Cifuentes Castaneda, Damian David ; Ramirez Duran, Ninfa ; Espinoza Rivera, Iliana ; Marcela Caro Gonzalez, Luz ; Pablo Antonio Moreno Perez, Martin ; Mendieta Zeron, Hugo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-15d1f8488cb4d971109b331bc0cbcd9733ebf8444cad058353bb9a3cd212660b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amikacin</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial resistance</topic><topic>Blood</topic><topic>Carbapenems</topic><topic>Cephalosporins</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug resistance</topic><topic>Epidemiology</topic><topic>Identification</topic><topic>Infections</topic><topic>Klebsiella</topic><topic>Klebsiella pneumoniae</topic><topic>Mortality</topic><topic>Multidrug resistance</topic><topic>Neonates</topic><topic>Opportunist infection</topic><topic>Pediatrics</topic><topic>Pneumonia</topic><topic>Polymerase chain reaction</topic><topic>rRNA 16S</topic><topic>Sepsis</topic><topic>Sulfamethoxazole</topic><topic>Trimethoprim</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cifuentes Castaneda, Damian David</creatorcontrib><creatorcontrib>Ramirez Duran, Ninfa</creatorcontrib><creatorcontrib>Espinoza Rivera, Iliana</creatorcontrib><creatorcontrib>Marcela Caro Gonzalez, Luz</creatorcontrib><creatorcontrib>Pablo Antonio Moreno Perez, Martin</creatorcontrib><creatorcontrib>Mendieta Zeron, Hugo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Jundishapur journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cifuentes Castaneda, Damian David</au><au>Ramirez Duran, Ninfa</au><au>Espinoza Rivera, Iliana</au><au>Marcela Caro Gonzalez, Luz</au><au>Pablo Antonio Moreno Perez, Martin</au><au>Mendieta Zeron, Hugo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection</atitle><jtitle>Jundishapur journal of microbiology</jtitle><date>2018-03-01</date><risdate>2018</risdate><volume>11</volume><issue>3</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2008-3645</issn><eissn>2008-4161</eissn><abstract>Background: The opportunistic pathogen Klebsiella pneumoniae is one of the main causes of pediatric bacterial blood stream infections (BSI), which is complicated with sepsis and high mortality.Objectives: To identify atypical Klebsiella species affecting a sample of infected neonates with low antimicrobial response.Methods: Multidrug resistant blood cultures for Klebsiella from a Neonatal Service, were submitted to molecular identification by sequencing analysis of 16S ribosomal RNA.Results: The mean age of the newborns was 14.7 ± 5.6 days. A total of 6 out of 8 cases were sepsis, 1 case of pneumonia, and 1 a catheter-related infection. The molecular identification showed 3 cases of K. pneumoniae subsp. ozaenae, 2 of K. pneumoniae and K. variicola, and 1 case of K. oxytoca. The highest antimicrobial resistance was against cephalosporins and Trimethoprim/sulfamethoxazole.Conclusions: Klebsiella pneumoniae subsp. ozaenae was responsible for multidrug resistant strains of Klebsiella even in 37.5% of cases. In our clinical setting, the use of Amikacin and carbapenems are still useful to treat neonatal infections by Klebsiella even against K. variicola, which is the most resistant.</abstract><cop>Ahvaz</cop><pub>Ahvaz Jundishapur University of Medical Sciences</pub><doi>10.5812/jjm.62393</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amikacin Antimicrobial agents Antimicrobial resistance Blood Carbapenems Cephalosporins Deoxyribonucleic acid DNA Drug resistance Epidemiology Identification Infections Klebsiella Klebsiella pneumoniae Mortality Multidrug resistance Neonates Opportunist infection Pediatrics Pneumonia Polymerase chain reaction rRNA 16S Sepsis Sulfamethoxazole Trimethoprim |
| title | Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection |
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