PA-457: A Potent HIV Inhibitor That Disrupts Core Condensation by Targeting a Late Step in Gag Processing

New HIV therapies are urgently needed to address the growing problem of drug resistance. In this article, we characterize the anti-HIV drug candidate 3-O-(3′,3′-dimethylsuccinyl) betulinic acid (PA-457). We show that PA-457 potently inhibits replication of both WT and drug-resistant HIV-1 isolates a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-11, Vol.100 (23), p.13555-13560
Hauptverfasser:	Li, F., Goila-Gaur, R., Salzwedel, K., Kilgore, N. R., Reddick, M., Matallana, C., Castillo, A., Zoumplis, D., Martin, D. E., Orenstein, J. M., Allaway, G. P., Freed, E. O., Wild, C. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Antivirals Binding Sites Biological Sciences Drug Design Drugs gag Gene Products, Human Immunodeficiency Virus Gag protein Gene Products, gag - antagonists & inhibitors Gene Products, gag - chemistry Genotype HeLa Cells HIV HIV 1 HIV Core Protein p24 - metabolism Human immunodeficiency virus Human immunodeficiency virus 1 Humans Inhibitory Concentration 50 Medical research Medical treatment Microscopy, Electron Models, Chemical Models, Genetic Mutation Plasmids - metabolism Precipitin Tests Proteins Succinates - chemistry Succinates - pharmacology Triterpenes - chemistry Triterpenes - pharmacology Viral morphology Virions Virus replication Viruses
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