Nicotine activates TRPM5-dependent and independent taste pathways

The orosensory responses elicited by nicotine are relevant for the development and maintenance of addiction to tobacco products. However, although nicotine is described as bitter tasting, the molecular and neural substrates encoding the taste of nicotine are unclear. Here, rats and mice were used to...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (5), p.1596-1601
Hauptverfasser:	Oliveira-Maia, Albino J, Stapleton-Kotloski, Jennifer R, Lyall, Vijay, Phan, Tam-Hao T, Mummalaneni, Shobha, Melone, Pamela, DeSimone, John A, Nicolelis, Miguel A.L, Simon, Sidney A
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animals Behavioral neuroscience Biological Sciences Cigarette smoking Electrodes Genes Genotype & phenotype Genotypes Gustatory discrimination Gustatory perception Mecamylamine - administration & dosage Mice Mice, Knockout Nerves Neurons Nicotine Nicotine - pharmacology Nicotinic Antagonists - administration & dosage Proteins Quinine - pharmacology Rats Receptors Reverse Transcriptase Polymerase Chain Reaction Rodents Taste Taste - drug effects Taste - physiology Taste buds Tobacco TRPM Cation Channels - physiology
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