Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) combination-based therapy has benefitted newly diagnosed acute promyelocytic leukemia (APL) in short-term studies, but the long-term efficacy and safety remained unclear. From April 2001, we have followed 85 patients administrated ATRA/ATO with a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-03, Vol.106 (9), p.3342-3347
Hauptverfasser:	Hu, Jiong, Liu, Yuan-Fang, Wu, Chuan-Feng, Xu, Fang, Shen, Zhi-Xiang, Zhu, Yong-Mei, Li, Jun-Min, Tang, Wei, Zhao, Wei-Li, Wu, Wen, Sun, Hui-Ping, Chen, Qiu-Sheng, Chen, Bing, Zhou, Guang-Biao, Zelent, Arthur, Waxman, Samuel, Wang, Zhen-Yi, Chen, Sai-Juan, Chen, Zhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute promyelocytic leukemia Aquaporins - genetics Aquaporins - metabolism Arsenic Arsenicals - adverse effects Arsenicals - therapeutic use Biological Sciences Blood Cells Chemotherapy Disease remission Gene Expression Regulation, Leukemic - drug effects Leukemia Leukemia, Promyelocytic, Acute - diagnosis Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Leukocytes Medical prognosis Medical treatment Mutation Myeloid leukemia Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oxides - adverse effects Oxides - therapeutic use Prognosis Relapse Survival Rate Time Factors Toxicity Tretinoin - adverse effects Tretinoin - therapeutic use Urine
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