Dynamics and processes of copy number instability in human [gamma]-globin genes

Copy number variation in the human genome is prevalent but relatively little is known about the dynamics of DNA rearrangement. We therefore used the duplicated ...-globin genes as a simple system to explore de novo copy number changes. Rearrangements that changed gene number were seen in both germli...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-05, Vol.107 (18), p.8304
Hauptverfasser:	Neumann, Rita, Lawson, Victoria E, Jeffreys, Alec J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell division Chromosomes Deoxyribonucleic acid DNA Genes Molecules Mutation
Online-Zugang:	Volltext
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